Honeywell North 7581P100L Organic Vapor / P100 Cartridge — North Bayonet

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Read our hands-on Honeywell North 7581P100L review for field-tested buyer notes.

Honeywell North 7581P100L Organic Vapor / P100 Cartridge Overview

The Honeywell North 7581P100L organic vapor P100 cartridge is a NIOSH-approved combination cartridge that snaps onto North bayonet half- and full-face respirators to protect against organic solvent vapors AND airborne particulate in one unit. The built-in P100 filter captures at least 99.97% of particles, so the 7581P100L covers solvent vapor plus dust, mist and fume without a separate prefilter. If you are deciding which cartridge you need, start with our guide to choosing a respirator cartridge and the Honeywell North cartridge guide, then confirm the markings on the respirator cartridge color chart.

As a Honeywell North OV/P100 cartridge, the 7581P100L belongs to the Honeywell North respirator filters and cartridges family. Buy it when you face solvent vapor and dust together; choose the gas-only N75001L if there is no particulate, or a different cartridge for acid gas or ammonia.

Where the 7581P100L Fits in Cartridge Selection

Confirm the hazards before the cartridge. The 7581P100L handles organic vapor AND airborne particulate — the two most common combination in finishing and solvent work. If you are weighing gas-only versus combination cartridges, our organic vapor vs P100 guide and respirator filter types explained walk through when the integrated P100 is worth it.

Who Should Buy the 7581P100L?

Buy it if your work mixes solvent vapor with dust or overspray — spray painting, refinishing, fiberglass and resin work. Choose another cartridge if your hazard is different: pick the gas-only N75001L for organic vapor with no dust, the 7582P100L for acid gas + P100, the 7583P100L for OV/AG + P100, or the 75SCP100L for multi-gas + P100.

What Does the 7581P100L Protect Against?

What the 7581P100L Does NOT Protect Against

The 7581P100L does not stop acid gases (choose the 7582P100L or 7583P100L), ammonia, or formaldehyde (use the 75SCP100L for a broader gas mix with P100).

No air-purifying cartridge makes a dangerous atmosphere safe. Never use the 7581P100L in an oxygen-deficient or IDLH (immediately dangerous to life or health) atmosphere, in unknown concentrations, or against gases with no warning properties — those conditions require a supplied-air or SCBA system, not a cartridge respirator.

Best Applications

Spray painting & refinishing

The 7581P100L is a top pick for spray work because it captures both the solvent vapor and the paint overspray in one cartridge. See the broader options in our best respirator for paint fumes guide.

Fiberglass, resin & solvent work with dust

Composite and resin tasks throw both vapor and particulate, exactly what the integrated P100 handles. Compare it to the gas-only option in our N75001L vs 7581P100L guide.

Pros & Cons

Compatible North Respirators

The 7581P100L uses the North bayonet connection, so it mounts on the North half-mask respirators (5500 and 7700 series) and North full-face respirators (5400 and 7600 series). The P100 filter is integrated, so no separate prefilter or retainer is needed. It does not fit 3M or MSA facepieces.

7581P100L vs Other North Cartridges

7581P100L vs the Alternatives

If you are weighing the 7581P100L against another North cartridge, the decision comes down to your gas hazard and whether dust is present:

• 7581P100L vs N75001L: same organic vapor protection, but the 7581P100L adds a P100 filter for dust. Full comparison →
• 7581P100L vs 7583P100L: both add P100, but the 7583P100L also covers acid gas. Full comparison →
• 7581P100L vs 7580P100: the 7580P100 is P100 particulate only; the 7581P100L adds organic vapor.

7581P100L Quick Answers

Does the 7581P100L need a separate filter?

No — the P100 particulate filter is built in, so there is no prefilter or retainer to add. It is ready for both vapor and dust out of the box.

What do the colors on the 7581P100L mean?

Magenta marks the P100 particulate side and black marks the organic vapor side; confirm both on the cartridge color chart.

Does the 7581P100L fit North 5500 and 7700 respirators?

Yes. The North bayonet connection fits the 5500 and 7700 series half masks and the 5400 and 7600 series full-face respirators.

Is the 7581P100L good for spray paint?

Yes — it captures the solvent vapor and the overspray together, which is why painters favor the OV/P100 combination.

7581P100L Specifications

Helpful Buying Guides

• Honeywell North cartridge guide
• How to choose a respirator cartridge
• Organic vapor vs P100
• Respirator cartridge color chart
• Respirator filter types explained
• Best respirator for paint fumes

Honeywell North 7581P100L Frequently Asked Questions

What does the Honeywell North 7581P100L protect against?

The 7581P100L is an organic vapor / P100 combination cartridge. It adsorbs organic solvent vapors and filters at least 99.97% of airborne particulate, covering solvent vapor plus dust, mist and fume. It does not protect against acid gas, ammonia or formaldehyde.

Does the Honeywell North 7581P100L filter dust?

Yes. Unlike the gas-only N75001L, the 7581P100L has a built-in P100 filter that captures at least 99.97% of airborne particles, including oil-based mists. No separate prefilter is needed.

Which respirators does the 7581P100L fit?

It uses the North bayonet connection, so it fits North 5500 and 7700 series half masks and North 5400 and 7600 series full-face respirators. It does not fit 3M or MSA respirators.

What is the difference between the 7581P100L and the N75001L?

Both protect against organic vapor, but the 7581P100L adds a P100 filter for dust and mist. Choose the N75001L if there is no dust; the 7581P100L when both are present.

What does P100 mean on the 7581P100L?

P100 is the highest NIOSH particulate rating: oil-proof and at least 99.97% efficient.

Is the 7581P100L NIOSH-approved?

Yes, for organic vapor and P100 particulate under 42 CFR Part 84. You can verify it against the NIOSH Certified Equipment List.

How often should I replace the 7581P100L?

Replace the gas portion on a change-out schedule or when you detect vapor, and replace when breathing through the P100 filter becomes noticeably harder.

Can I use the 7581P100L for spray painting?

Yes — it captures both the solvent vapor and the paint overspray in one cartridge, with no separate filter to add.

Does the 7581P100L protect against acid gas?

No. It is organic vapor plus P100 only. For acid gas with particulate use the 7582P100L; for OV and acid gas with particulate use the 7583P100L.

Is this the genuine Honeywell North 7581P100L cartridge?

Yes. WC Safety sells authentic, NIOSH-approved Honeywell North 7581P100L cartridges through legitimate supply channels.

Can I buy the 7581P100L in bulk or by the case?

Yes. Use the Request a Quote option for case and pallet pricing on volume orders.

How should I store the 7581P100L?

Store it sealed in its original packaging, away from solvents and dust, so neither the gas nor filter service life is used up before you wear it.