MSA 815180 GMC-P100 OV / Acid Gas / P100 Cartridge for Comfo Respirators — Box of 6

MSA GMC-P100 Overview

The MSA GMC-P100 (part number 815180) is a NIOSH-approved OV/AG/P100 triple-combination cartridge that simultaneously controls organic vapors, acid gases, and P100-rated particulates (≥99.97% efficiency) in a single bayonet-mount unit — sold as a box of six cartridges at $46.47, or roughly $7.75 per cartridge. It threads onto the MSA full-face respirator and MSA half-mask respirator models in the Comfo Classic, Comfo II, Ultra-Twin, and Ultra-Elite lines via the MSA GM-series threaded bayonet mount. For a broader look at how combination cartridges compare to stand-alone filters, see the respirator filter types guide and the respirator cartridge selection guide.

Affiliate disclosure: WC Safety earns a commission on Amazon purchases at no cost to you.

Where the GMC-P100 Fits in Respirator Selection

Start cartridge selection by confirming the hazard class. The GMC-P100 is appropriate when your industrial hygiene assessment identifies organic vapors (e.g., solvents, paint thinners, hydrocarbons), acid gases (e.g., hydrogen chloride, sulfur dioxide, chlorine), and fine particulates as co-present hazards. If the assessment shows only organic vapors and particulates, the lighter MSA GMA-P100 OV/particulate cartridge is the better fit — you avoid paying for acid gas capacity you do not need. If the assessment identifies organic vapors and acid gases but no significant particulate loading, the MSA GMC OV/acid gas cartridge (no P100) is sufficient. When ammonia or methylamine is also present, none of the GMC variants cover it — the correct choice is the MSA GME-P100 multi-gas cartridge. For a visual guide to matching hazard class to cartridge color, see the respirator cartridge color chart guide.

Who Should Buy the GMC-P100?

Buy the GMC-P100 if:

• You already own an MSA Comfo Classic, Comfo II, Ultra-Twin, or Ultra-Elite respirator with bayonet-mount ports.
• Your SDS review or air monitoring confirms co-exposure to organic vapors, acid gases, and particulates.
• You prefer one cartridge over two separate cartridge-plus-prefilter assemblies to reduce change-out complexity.
• You are in automotive refinishing, chemical handling, semiconductor fab, or industrial coating and need an end-of-service-life indicator-free cartridge with a scheduled change-out program.

Do not buy the GMC-P100 if:

• Your respirator uses MSA Advantage snap-on ports — those accept the MSA Advantage P100 filter or MSA Advantage N95 cover, not GM-series cartridges.
• Ammonia or methylamine is present — use the MSA GMD-P100 or MSA GME-P100.
• You need mercury vapor control — use the MSA Mersorb P100.
• You use a 3M, Moldex, or Honeywell North respirator — those brands use proprietary connection systems incompatible with GM-series cartridges. See our 3M respirator filters or Moldex cartridges for those platforms.

What Does the GMC-P100 Protect Against?

The GMC-P100 carries NIOSH approval under 42 CFR Part 84 for the following three hazard categories simultaneously:

What the GMC-P100 Does NOT Protect Against

• Ammonia and methylamine — not covered; use the MSA GMD-P100.
• Mercury vapor — not covered; use the MSA Mersorb P100.
• Formaldehyde — not covered at rated levels; consult your IH for a dedicated formaldehyde cartridge.
• Carbon monoxide and other gases lacking adsorption affinity for activated carbon — not covered.
• Radioactive particles — not rated for radiological use without a specific NIOSH approval for that purpose.

Best Applications for the GMC-P100

Automotive Refinishing and Body Shops

Paint spraying and clear-coat application create simultaneous solvent vapor, isocyanate-adjacent acid gas, and paint mist hazards — exactly the triple-combination the GMC-P100 addresses on Comfo/Ultra respirators. Combine with a scheduled change-out program based on your paint-booth ventilation rate and solvent concentration. For more background, see the organic vapor vs P100 filter comparison.

Chemical Manufacturing and Handling

Workers sampling, transferring, or processing organic solvents alongside acid gas-generating processes (e.g., chlorination, sulfonation) benefit from a single cartridge that addresses both vapor streams plus any fine particulate generated in the process. Review your SDS stack to confirm no ammonia or mercury co-exposure before specifying the GMC-P100 over the MSA GME-P100 multi-gas variant.

Industrial Coating and Maintenance Painting

Epoxy, urethane, and catalyzed coatings off-gas both organic vapors and acid-adjacent components. The P100 layer provides simultaneous protection against airborne paint pigment particles and any metal-bearing spray mist. The best respirator for welding fumes guide walks through related P100 filter selection logic applicable to metal spray applications.

Semiconductor Fabrication and Lab Environments

Wet etch, deposition, and cleaning operations often co-generate organic solvents, corrosive acid gases (HCl, HF where APF allows), and fine particulate. The GMC-P100's three-layer construction — P100 filter face, carbon bed, and impregnated sorbent layer — delivers this coverage in a single cartridge on the MSA full-face respirator platform.

GMC-P100 Pros and Cons

Compatible MSA Respirators

The GMC-P100 uses the MSA GM-series threaded bayonet mount. Confirm your respirator model before ordering — MSA makes two distinct connection systems that are NOT interchangeable.

MSA GMC-P100 vs Other MSA GM-Series Cartridges

All cartridges below use the same GM-series bayonet mount and are sold in the MSA respirator filters and cartridges collection.

MSA GMC-P100 vs MSA GMC (Without P100)

Both cartridges cover the same OV and acid gas hazard classes on the same GM-series bayonet respirators. The difference is the P100 particulate layer: the MSA GMC OV/acid gas cartridge omits it, making it appropriate only when your IH assessment confirms negligible airborne particulate. In any environment with dusts, mists, or metal fumes co-present with vapors, the GMC-P100 is the required choice — P100 filtration is mandatory, not optional, when particulate hazards are confirmed. The trade-off is slightly higher breathing resistance and a higher per-unit cost with the P100 version.

MSA GMC-P100 vs MSA GME-P100 Multi-Gas Cartridge

The MSA GME-P100 multi-gas cartridge adds ammonia and methylamine coverage to everything the GMC-P100 offers. If your SDS review confirms no ammonia or methylamine in the work environment, the GMC-P100 delivers the same vapor and particulate protection at a lower cost. If ammonia is confirmed, the GME-P100 is mandatory — the GMC-P100 provides no rated protection against it. Both cartridges use the identical GM-series bayonet mount and are interchangeable on the same respirator body. For side-by-side hazard mapping across the entire MSA filter line, see the respirator cartridge selection guide.

MSA GMC-P100 vs MSA GMA-P100

The MSA GMA-P100 OV/particulate cartridge covers organic vapors and P100 particulates but carries no acid gas rating. If your job involves pure solvent exposure with no acid gas co-generation — such as adhesive application or single-solvent degreasing — the GMA-P100 is the leaner, lower-cost option. The moment chlorine, HCl, SO₂, or another acid gas appears in the SDS hazard review, the GMC-P100 is required. Under-protecting against acid gas is a compliance failure; always match the cartridge to the full confirmed hazard profile, not the primary one.

MSA GMC-P100 Quick Answers

What is the MSA GMC-P100?

The MSA GMC-P100 (part number 815180) is a NIOSH-approved triple-combination air-purifying cartridge that provides simultaneous protection against organic vapors, acid gases, and P100-class particulates (≥99.97% filtration efficiency). It attaches via a threaded bayonet mount to MSA Comfo Classic, Comfo II, Ultra-Twin, and Ultra-Elite respirators and is sold in boxes of six at $46.47 ($7.75 per cartridge).

What respirators does the MSA GMC-P100 fit?

The GMC-P100 fits MSA Comfo Classic, Comfo II, Ultra-Twin, and Ultra-Elite respirators — all of which use the GM-series threaded bayonet port. It does not fit MSA Advantage-series respirators, which use a separate snap-on bayonet system, nor does it fit 3M, Moldex, or Honeywell North respirators.

Is the MSA GMC-P100 the same as the MSA GMC cartridge?

No. The MSA GMC covers organic vapors and acid gases only; the GMC-P100 adds a P100 particulate filtration layer to the same OV and acid gas protection. They share the same connection system and hazard class coverage for vapors and gases, but you must choose the GMC-P100 whenever particulates are part of the confirmed exposure profile.

Does the MSA GMC-P100 protect against chlorine gas?

Yes. Chlorine (Cl₂) falls within the NIOSH acid gas classification. The impregnated sorbent layer in the GMC-P100 is rated to control acid gases including chlorine within the cartridge's service life and at atmospheric concentrations that keep exposures within the respirator's assigned protection factor. Confirm concentration levels against your IH data before relying solely on the cartridge.

How many cartridges are in a box of MSA GMC-P100?

Each box contains six (6) cartridges. At $46.47 per box, the per-cartridge cost is approximately $7.75. For full-face Ultra-Twin and Ultra-Elite respirators, which require two cartridges simultaneously, one box supplies three full change-outs.

Does the MSA GMC-P100 have an end-of-service-life indicator (ESLI)?

No. The GMC-P100 does not have a built-in ESLI. Users must follow a documented change-out schedule developed by a qualified industrial hygienist based on contaminant concentration, work duration, temperature, and humidity. OSHA's assigned protection factors and NIOSH's COSHH/ESLI guidance should inform that schedule.

Can I use the MSA GMC-P100 for spray painting?

Yes, for spray painting environments where organic vapors (solvent-based paints and thinners), acid-adjacent catalyst off-gassing, and paint mist particulates are the primary hazards, and where the work atmosphere is within the cartridge's rated APF. Pair with a properly fitted Comfo or Ultra-series respirator, confirm a positive/negative pressure fit check before each use, and follow a change-out schedule tied to your specific paint product's solvent concentration. See the OV vs P100 guide for additional spray painting cartridge selection context.

MSA GMC-P100 Specifications

Helpful Buying Guides

• How to Choose a Respirator Cartridge — Step-by-Step Selection Guide
• Respirator Filter Types Explained (P100, N95, OV, AG, Combo)
• Organic Vapor vs P100: When You Need Each and When You Need Both
• Respirator Cartridge Color Chart — NIOSH Color Codes Decoded
• Best Respirator for Silica Dust (2026) — P100 and Combo Options Compared
• Best Respirator for Welding Fumes — P100 Filter Selection Guide
• 3M Filter and Cartridge Guide — Cross-Reference and Selection

MSA GMC-P100 Frequently Asked Questions

What is the part number for the MSA GMC-P100 cartridge?

The MSA part number for the GMC-P100 OV / Acid Gas / P100 combination cartridge is 815180. The GTIN is 0641817011065. This is the box-of-six configuration sold at $46.47.

Can I use the MSA GMC-P100 with the MSA Advantage 200 LS respirator?

No. The MSA Advantage 200 LS (and other Advantage-series half-masks) uses a snap-on bayonet port that accepts Advantage-series filters only — it is a different and incompatible connection system from the GM-series threaded bayonet used by the GMC-P100. Do not attempt to force-fit GM-series cartridges onto Advantage respirators; use the MSA Advantage P100 filter with splash guard for P100 protection on the Advantage platform instead.

How often do I need to replace the MSA GMC-P100?

There is no universal replacement interval — the correct change-out frequency must be determined by a qualified industrial hygienist based on the specific contaminants present, their airborne concentration, the duration and frequency of use, temperature, humidity, and work rate. OSHA requires a written change-out schedule when no ESLI is available. As a starting point, MSA and NIOSH provide guidance frameworks, but task-specific IH data drives the final schedule.

Does the MSA GMC-P100 protect against hydrogen sulfide (H₂S)?

H₂S is classified as an acid gas, and the GMC-P100's impregnated sorbent layer is designed for acid gas protection. However, always verify the NIOSH approval certificate and the product's specific approved contaminant list against your H₂S concentration levels and confirm that the expected concentration falls within the cartridge's protection capacity for that specific gas at your work conditions. High H₂S concentrations may require supplied-air protection.

Is the MSA GMC-P100 the same as the 3M 60923 or Honeywell 7583P100L?

All three are NIOSH-approved OV/AG/P100 triple-combination cartridges in the same hazard class, but they are not interchangeable. Each uses a brand-specific connection system: the GMC-P100 uses the MSA GM-series threaded bayonet, the 3M 60923 uses 3M's bayonet, and the Honeywell 7583P100L uses Honeywell North's thread. You must match the cartridge to your specific respirator brand and model. See our 3M respirator cartridges page for 3M platform options.

Do I need one or two GMC-P100 cartridges per respirator?

Half-mask respirators (Comfo Classic, Comfo II) require two cartridges — one per port (left and right). Full-face Ultra-Twin and Ultra-Elite respirators also use two cartridges simultaneously. One box of six cartridges therefore supplies three complete set changes for any of these respirators.

Can the MSA GMC-P100 be used for paint spray booths?

Yes, when the primary hazards are solvent vapors, acid-adjacent components (e.g., isocyanate catalyst off-gassing at levels within APF), and paint mist particulates, the GMC-P100's OV/AG/P100 triple coverage is appropriate. Ensure the booth ventilation design, spray product SDS, and your IH assessment all confirm that the hazards are within the APF of your specific respirator (APF 10 for half-mask, APF 50 for full-face). Perform a fit check before each use.

Is the MSA GMC-P100 approved for silica dust?

Yes. The P100 particulate layer provides ≥99.97% filtration efficiency, making it effective against respirable crystalline silica dust when paired with a properly fitted, NIOSH-approved respirator. For silica-specific selection guidance across multiple respirator platforms, see the best respirator for silica dust guide.

What is the APF of the MSA GMC-P100?

The APF is determined by the respirator worn, not the cartridge alone. An APF of 10 applies when used with an MSA Comfo Classic or Comfo II half-mask. An APF of 50 applies when used with an MSA Ultra-Twin or Ultra-Elite full-face respirator. The cartridge itself must be paired with a properly fitted, NIOSH-approved respirator to achieve the stated APF.

Where can I buy the MSA GMC-P100 online?

The MSA GMC-P100 (part 815180) is available from WC Safety on Amazon. You can purchase a box of six at Amazon (ASIN B00GOA6UBI) with the $46.47 box price. WC Safety is an authorized MSA Safety retailer.

Can I use the MSA GMC-P100 with a 3M full-face respirator?

No. The GMC-P100 uses the MSA GM-series threaded bayonet connection, which is incompatible with 3M bayonet or thread standards. If you own a 3M full-face respirator and need OV/AG/P100 triple-combination coverage, the correct cartridge is a 3M-compatible option from our 3M respirator filter and cartridge collection.

Does the MSA GMC-P100 protect against sulfur dioxide (SO₂)?

Sulfur dioxide is classified within the acid gas category. The GMC-P100's impregnated sorbent layer is rated for acid gas protection, which includes SO₂ among the approved acid gas contaminants. Verify the actual air concentration against your respirator's APF and confirm through your IH program that the GMC-P100 service life is adequate for the specific SO₂ exposure scenario before use.