MSA 815357 Advantage GMC OV/Acid Gas Respirator Cartridge, 2-Pack

MSA 815357 GMC OV/Acid Gas Cartridge Overview

The MSA 815357 is a NIOSH-certified combination organic vapor and acid gas respirator cartridge that snaps onto MSA Advantage series half-mask and full-facepiece respirators via the twin-port snap-on bayonet mount. It is sold as a matched pair (2 cartridges) and carries NIOSH's olive/yellow-green color designation for OV plus acid gas combination protection. This cartridge is designed for co-exposure environments where both solvent vapors and acid gases appear on the same Safety Data Sheet.

The GMC cartridge addresses one of the most common dual-hazard scenarios in industrial settings: a process that generates organic vapors from solvents alongside acidic byproducts or cleaning agents. Without a combination cartridge, workers would need two separate cartridge types — the GMC handles both hazard classes in a single unit. For background on how OV and acid gas protection layers work, see our guide Respirator Filter Types Explained. To confirm this is the right selection for your specific chemical exposure, consult our complete respirator cartridge selection guide. Browse all MSA Advantage respirator filters and cartridges or narrow to organic vapor cartridges for side-by-side comparisons.

Where the MSA 815357 GMC Fits in Respirator Selection

Combination OV/acid gas cartridges occupy a specific tier in respirator selection: they are required when a workplace's air monitoring or SDS confirms that both organic vapors and acid gases are simultaneously present at concentrations above the action level. Using a vapor-only cartridge like the MSA 815355 GMA in an acid gas environment provides zero acid gas protection, leaving the worker unprotected against chlorine, HCl, SO₂, and related hazards.

The selection decision for the 815357 hinges on three questions: (1) Are organic vapors present? (2) Are acid gases present? (3) Are particulates also present? The GMC answers yes to the first two; if particulates are also on your SDS, add an MSA 815369 LP P100 prefilter to the GMC, or replace the GMC entirely with the MSA 815364 GMC-P100. If ammonia or methylamine is also present, the MSA 815359 GME Multi-Gas adds that coverage at the same price. Our respirator cartridge color chart guide maps NIOSH color codes to hazard classes and is a useful cross-check for selecting the right cartridge from your SDS.

Who Should Buy the MSA 815357 GMC Cartridge?

Buy the 815357 GMC if:

• You already own an MSA Advantage 200LS, 420, 1000, 3000, or 4000 series respirator and need OV plus acid gas replacement cartridges.
• Your SDS or industrial hygiene assessment confirms simultaneous exposure to organic solvents AND one or more acid gases: Cl₂, SO₂, ClO₂, HCl, or H₂S (escape-only for H₂S).
• You work in chemical processing, laboratory environments, semiconductor fabrication cleaning, or industrial maintenance where acidic cleaning agents and organic solvents are both used.
• You want a single-cartridge solution for dual vapor/acid gas hazards without paying for P100 particulate filtration you do not need.
• Your environment is vapor-only with no significant airborne dust or mist component.

Choose a different cartridge if:

• OV only, no acid gases → MSA 815355 GMA OV cartridge at $32.00 saves $2 per pack.
• Acid gas only, no OV → MSA 815356 GMB Acid Gas at $23.90 covers acid gases without OV sorbent.
• Ammonia or methylamine also present → MSA 815359 GME Multi-Gas adds ammonia/methylamine protection at the same $34.00 price.
• Particulates, dust, or mist also present → MSA 815364 GMC-P100 adds P100 filtration for $47.00.
• Mercury vapor or chlorine P100 application → MSA 815368 Mersorb is the specialized choice.
• You own an MSA Comfo Classic, Comfo II, Ultra Elite, or Ultra-Twin respirator → those platforms use a different connection; Advantage-series cartridges will not physically fit.

What Does the MSA 815357 GMC Protect Against?

Hazard Class	Protection Status	Buyer Guidance
Organic solvent vapors (acetone, toluene, MEK, xylene, naphtha)	✅ Protected (OV)	Primary OV use case; chemical boiling point must be above 65 °C (150 °F)
Chlorine (Cl₂)	✅ Protected (Acid Gas)	Key driver for this cartridge in water treatment and chemical processing
Sulfur dioxide (SO₂)	✅ Protected (Acid Gas)	Common in chemical manufacturing and combustion environments
Chlorine dioxide (ClO₂)	✅ Protected (Acid Gas)	Used in pulp/paper bleaching and water disinfection
Hydrogen chloride / hydrochloric acid vapor (HCl)	✅ Protected (Acid Gas)	Common in semiconductor etching, pickling, and lab acid work
Hydrogen sulfide (H₂S)	✅ Escape only	NIOSH-rated for emergency escape; not rated for routine H₂S work entry
Paint vapors, lacquers, varnishes	✅ Protected (OV)	Add LP P100 prefilter if overspray mist is also present
Ammonia / methylamine	❌ Not Protected	Use MSA 815359 GME if ammonia is present
Airborne dust, mist, or fume particulates	❌ Not Protected	Add MSA 815369 LP P100 prefilter or use 815364 GMC-P100
Mercury vapor	❌ Not Protected	Use MSA 815368 Mersorb for mercury vapor

What the MSA 815357 GMC Does NOT Protect Against

• Ammonia and methylamine — the GMC sorbent does not capture alkaline gases. Use MSA 815359 GME Multi-Gas when ammonia or methylamine appears on the SDS.
• Airborne particulates (dust, mist, fume) — the GMC cartridge contains no particulate filter media. Attach the MSA 815369 LP P100 prefilter over the GMC when dust or mist is co-present, or step up to the MSA 815364 GMC-P100 combination cartridge.
• Mercury vapor — requires the specialized Mersorb sorbent found in the MSA 815368 Mersorb cartridge.
• Radioiodine — use MSA 815641 GMI/P100 for radioiodine and radiological particulate applications.
• Chemicals with boiling points below 65 °C (150 °F) — very low-boiling solvents such as methyl chloride break through activated carbon sorbent rapidly; verify with your industrial hygienist.
• H₂S routine entry — H₂S protection is rated for escape only; do not use the GMC for routine entry into hydrogen sulfide atmospheres.
• Non-MSA Advantage respirators — the snap-on bayonet mount is MSA Advantage-specific and will not connect to MSA Comfo Classic, Comfo II, Ultra Elite, Ultra-Twin, or any non-MSA half-mask or full-facepiece.

Best Applications for the MSA 815357 GMC Cartridge

Chemical Processing and Industrial Labs

Chemical plants and industrial laboratories routinely handle processes that generate both organic solvent vapors and acid gas byproducts simultaneously. Reactor cleaning with solvent followed by acid rinse, distillation operations, and chemical synthesis steps involving both organic and inorganic reagents are all classic GMC use cases. Workers on these tasks need a cartridge that responds to both hazard classes without requiring a mid-task cartridge swap. The MSA 815357 GMC, paired with an MSA Advantage half-face respirator or full-face respirator, provides that dual coverage in a single matched pair. For labs where particulates are also a concern — catalyst dust, precipitate handling — add the MSA 815369 LP P100 prefilter.

Semiconductor and Electronics Cleaning

Semiconductor fabrication and electronics cleaning involves etchants (HF, HCl, H₂SO₄ precursors) used alongside organic solvents (isopropyl alcohol, acetone, NMP) for wafer cleaning, photoresist stripping, and substrate preparation. The acid gas component — particularly hydrogen chloride vapor from HCl-based etchants — makes a vapor-only OV cartridge insufficient. The GMC's combined OV and acid gas protection addresses both hazard classes present in cleanroom chemical handling. Workers using MSA Advantage respirators in this environment — particularly those on the MSA Advantage 3000 or 4000 full-face — will find the 815357 a direct-fit solution for standard chemical handling tasks.

Multi-Hazard Solvent and Acid Gas Environments

Industrial cleaning operations, maintenance work in chemical plants, and surface treatment processes (pickling, passivation, anodizing) often expose workers to a rotating roster of chemicals across a single shift. A maintenance tech cleaning equipment with solvent before applying an acid descaler, or a process worker who rotates between organic vapor and acid gas tasks, benefits from a single cartridge type that covers both hazard classes throughout the shift. The MSA 815357 GMC eliminates the need to track multiple cartridge types and reduces the risk of using the wrong cartridge on a given task. See our organic vapor vs P100 guide and cartridge color chart for help confirming this is the right combination for your SDS.

MSA 815357 GMC — Pros and Cons

Compatible MSA Respirators for the 815357 GMC

The MSA 815357 GMC uses the MSA Advantage snap-on bayonet (twin-port) connection. It fits all respirators in the MSA Advantage platform and is incompatible with all other MSA respirator series and all non-MSA respirators.

Respirator	Type	GMC Fit
MSA Advantage 200LS	Half-mask	✅ Compatible
MSA Advantage 420	Half-mask	✅ Compatible
MSA Advantage 1000	Full-face	✅ Compatible
MSA Advantage 3000	Full-face	✅ Compatible
MSA Advantage 4000	Full-face	✅ Compatible
MSA Comfo Classic / Comfo II	Half-mask	❌ Incompatible — use Comfo GM-series
MSA Ultra Elite / Ultra-Twin	Full-face	❌ Incompatible — use Comfo GM-series
Any non-MSA respirator (3M, Honeywell, Moldex, etc.)	Any	❌ Incompatible

Browse MSA Advantage half-face respirators and MSA Advantage full-face respirators to confirm your facepiece before ordering cartridges.

MSA 815357 GMC vs Other MSA Advantage Cartridges

All MSA Advantage cartridges below use the same snap-on bayonet mount and are available at WC Safety. The 815357 GMC is highlighted.

Cartridge	Part #	OV	Acid Gas	Ammonia	P100	Price (2-pk)
GMA OV	815355	✅	—	—	—	$32.00
GMB Acid Gas	815356	—	✅	—	—	$23.90
GMC OV+AG ← You Are Here	815357	✅	✅	—	—	$34.00
GMD Ammonia	815358	—	—	✅	—	$19.00
GME Multi-Gas	815359	✅	✅	✅	—	$34.00
GMA-P100	815362	✅	—	—	✅	$38.00
GMB-P100	815363	—	✅	—	✅	$33.82
GMC-P100	815364	✅	✅	—	✅	$47.00
GME-P100	815366	✅	✅	✅	✅	$47.00
LP P100 Prefilter	815369	—	—	—	✅	$16.76

MSA 815357 GMC Head-to-Head Comparisons

MSA 815357 GMC vs MSA 815355 GMA — OV Only vs OV + Acid Gas

The MSA 815355 GMA ($32.00) protects against organic vapors only. The MSA 815357 GMC ($34.00) adds NIOSH-rated protection for Cl₂, SO₂, ClO₂, HCl, and H₂S (escape) at just $2 more per 2-pack. If there is any acid gas on your SDS — even trace levels of chlorine from bleach-based cleaners used in the same area — the GMC is the correct choice. Choose the GMA only when your industrial hygiene assessment has confirmed zero acid gas co-exposure.

MSA 815357 GMC vs MSA 815359 GME — Same Price, Different Gas Coverage

The MSA 815359 GME Multi-Gas is priced identically at $34.00 per 2-pack and adds ammonia and methylamine protection on top of everything the GMC covers. If your workplace uses any ammonia-based cleaners, refrigerants, or processes that produce methylamine, the GME delivers broader coverage at no extra cost. Choose the GMC over the GME only when you have confirmed there is no ammonia or methylamine exposure and prefer the simpler specification for procurement documentation.

MSA 815357 GMC vs MSA 815364 GMC-P100 — Adding Particulate Protection

The MSA 815364 GMC-P100 combines the same OV and acid gas protection as the GMC with an integrated P100 particulate filter, at $47.00 — a $13 premium per 2-pack. If your environment has any airborne dust, mist, or fume component (welding fumes, catalyst dust, acid mist), the GMC-P100 is the correct all-in-one choice. The GMC is the right pick only for pure vapor/gas environments where no particulate filter will ever be needed.

Quick Answers — MSA 815357 GMC

What gases does the MSA 815357 GMC protect against?

The MSA 815357 GMC is NIOSH-certified for organic vapors plus the following acid gases: chlorine (Cl₂), sulfur dioxide (SO₂), chlorine dioxide (ClO₂), hydrogen chloride (HCl), and hydrogen sulfide (H₂S) for escape only. It does not protect against ammonia, methylamine, particulates, or mercury vapor.

What respirators does the MSA 815357 fit?

The MSA 815357 GMC fits all MSA Advantage series respirators with the snap-on bayonet (twin-port) mount: Advantage 200LS and 420 half-masks, and Advantage 1000, 3000, and 4000 full-face respirators. It does not fit MSA Comfo Classic, Comfo II, Ultra Elite, Ultra-Twin, or any non-MSA respirator.

How many cartridges come in a pack?

The MSA 815357 is sold as a 2-pack — two matched cartridges, one for each side of the respirator. The $34.00 price is for the pair.

Does the GMC cartridge include particulate protection?

No. The MSA 815357 GMC is a chemical vapor/gas cartridge only — it contains no particulate filter media. For environments with dust, mist, or fume alongside vapors and acid gases, snap the MSA 815369 LP P100 prefilter onto the GMC, or replace it with the MSA 815364 GMC-P100.

What is the NIOSH color code for the MSA 815357?

The MSA 815357 GMC carries NIOSH's olive/yellow-green color designation, which denotes organic vapor plus acid gas combination protection. See our respirator cartridge color chart for a complete NIOSH color code reference.

Does the MSA 815357 have an End-of-Service-Life Indicator (ESLI)?

No. No MSA Advantage cartridge includes an ESLI. Per OSHA 29 CFR 1910.134, a written change-out schedule must be established using OSHA Appendix B guidance and the manufacturer's service life data before the cartridges are placed in service.

Should I choose the GMC or GME for chemical processing?

If your chemical processing SDS lists only organic vapors and acid gases (Cl₂, SO₂, HCl, ClO₂, H₂S), the GMC is sufficient. If ammonia or methylamine also appears on the SDS or process chemical list, the MSA 815359 GME Multi-Gas provides identical coverage plus ammonia/methylamine protection at the same $34.00 price.

MSA 815357 GMC Specifications

Part Number	815357
Product Name	MSA Advantage GMC OV/Acid Gas Respirator Cartridge
Brand	MSA Safety
Protection Type	Organic Vapor (OV) + Acid Gas (AG)
Acid Gases Covered	Cl₂, SO₂, ClO₂, HCl, H₂S (escape only)
NIOSH Certification	NIOSH-certified combination OV/AG cartridge
NIOSH Color Code	Olive / Yellow-Green (OV + Acid Gas combination)
Connection Type	MSA Advantage snap-on bayonet (twin-port)
Pack Quantity	2 cartridges per package (matched pair)
Compatible Respirators	MSA Advantage 200LS, 420, 1000, 3000, 4000
Incompatible Respirators	MSA Comfo Classic, Comfo II, Ultra Elite, Ultra-Twin; all non-MSA respirators
ESLI	None — written change-out schedule required (OSHA 1910.134)
Particulate Protection	None (add LP P100 prefilter 815369 for particulates)
Price (2-Pack)	$34.00

Helpful Buying Guides

• How to Choose a Respirator Cartridge — Complete Selection Guide
• Respirator Filter Types Explained — OV, Acid Gas, P100, and Combination
• Organic Vapor vs P100: Which Respirator Cartridge Do You Need?
• Respirator Cartridge Color Chart — NIOSH Color Code Reference
• P100 vs N95: What's the Difference and Which Do You Need?

MSA 815357 GMC Frequently Asked Questions

Is the MSA 815357 the same as the MSA GMC cartridge?

Yes. The MSA 815357 is the part number for the MSA Advantage GMC OV/Acid Gas Respirator Cartridge, sold as a 2-pack. GMC is the cartridge series designation; 815357 is the SKU used for ordering.

Can I use the MSA 815357 on a 3M or Honeywell respirator?

No. The MSA 815357 GMC uses MSA's snap-on bayonet (twin-port) connection, which is proprietary to the MSA Advantage platform. It will not physically attach to 3M, Honeywell North, Moldex, or any other brand of respirator. Each respirator brand uses a different cartridge connection standard.

Does the MSA 815357 protect against hydrofluoric acid (HF) vapor?

HF vapor is not listed in the published NIOSH certification for the MSA 815357 GMC. Hydrofluoric acid applications require verification against MSA's published service life data and may require a specialized cartridge. Consult your industrial hygienist before relying on the GMC for HF exposure.

How do I know when to change the MSA 815357 cartridges?

The MSA 815357 has no End-of-Service-Life Indicator. OSHA 29 CFR 1910.134 requires a written change-out schedule based on OSHA Appendix B guidance, manufacturer service life data, and your specific chemical concentrations, humidity, temperature, and work rate. Never rely on odor or taste as a breakthrough indicator — these are unreliable and can occur after dangerous exposure levels have been reached.

Can I snap an MSA LP P100 prefilter onto the 815357?

Yes. The MSA 815369 LP P100 Low-Profile Prefilter snaps directly onto the GMC cartridge, adding P100 particulate filtration for environments with both chemical vapors/gases and airborne dust or mist. This combination provides OV, acid gas, and P100 protection at a lower cost than replacing the GMC with the GMC-P100 combination cartridge, though the GMC-P100 is a cleaner integrated solution.

What is the price for the MSA 815357 at WC Safety?

The MSA 815357 GMC OV/Acid Gas Respirator Cartridge 2-Pack is priced at $34.00 at WC Safety. Also available on Amazon (ASIN B00L45E8P8).

WC Safety is a participant in the Amazon Services LLC Associates Program. As an Amazon Associate, WC Safety earns from qualifying purchases at no extra cost to you.

Is the GMC better than the GME for chemical labs?

Not categorically. Both are priced at $34.00. The MSA 815359 GME covers everything the GMC does plus ammonia and methylamine. In most chemical lab environments the GME provides equal or greater coverage at the same price. The GMC is the better choice only if your purchasing or safety documentation specifically requires a cartridge without ammonia coverage — for instance, if an SCBA or supplied-air system is designated for ammonia emergencies and you want the cartridge spec to reflect only the lower-hazard vapor/acid gas protection tier.

Does the MSA 815357 work with the MSA Advantage 420 half-mask?

Yes. The MSA Advantage 420 half-mask uses the same snap-on bayonet (twin-port) connection as all Advantage-series cartridges. The 815357 GMC installs on the 420 without tools — press and twist until the bayonet locks on both ports. Confirm cartridge fit before each use by checking that both bayonet locks are fully engaged.

Can the MSA 815357 be used for chlorine gas exposure?

Yes — chlorine (Cl₂) is listed in the acid gas protection coverage for the MSA 815357 GMC. It is one of the primary reasons buyers choose this cartridge over the vapor-only GMA. Verify that your chlorine exposure concentration is within the NIOSH-rated service limits for this cartridge and that a written change-out schedule is in place.

What is the difference between the GMC and GMC-P100?

The MSA 815357 GMC provides OV and acid gas protection only. The MSA 815364 GMC-P100 is an integrated combination cartridge that adds NIOSH P100 particulate filtration (99.97% efficiency against oil and non-oil aerosols) to the same OV and acid gas coverage, at $47.00 per 2-pack — $13 more than the GMC. Choose the GMC-P100 when dust, mist, metal fume, or other aerosols appear on the same SDS as your vapor and acid gas hazards.

How does the olive/yellow-green color code help me identify the 815357 in the field?

NIOSH assigns olive coloring to organic vapor and yellow-green to acid gas; combination OV/AG cartridges use both colors. The MSA 815357 carries this olive/yellow-green combination color code, making it visually distinguishable from pure OV (black), pure acid gas (white/green), P100 (magenta/purple), or ammonia (green) cartridges. Our NIOSH cartridge color chart guide maps every color code to its hazard class.

Where can I buy the MSA 815357 GMC cartridge?

The MSA 815357 is available directly on this page at $34.00 per 2-pack, and also through Amazon (ASIN B00L45E8P8). For volume orders or B2B procurement, contact WC Safety directly.