{"product_id":"3m-secure-click-d80921-organic-vapor-p100-combination-cartridge-1-pair","title":"3M Secure Click D80921 Organic Vapor P100 Combination Cartridge, 1 Pair","description":"\u003c!-- ============================================================\n     Product description body_html\n     Product: 3M Secure Click D80921 Organic Vapor P100 Combination Cartridge, 1 Pair\n     Handle: 3m-secure-click-d80921-organic-vapor-p100-combination-cartridge-1-pair\n     Shopify GID: gid:\/\/shopify\/Product\/8784570187864\n     Primary keyword: 3M Secure Click D80921 OV P100 combination cartridge\n     Last updated: 2026-05-25\n     ============================================================ --\u003e\n\n\u003c!-- DOM #1 — Editorial review callout --\u003e\n\u003cdiv style=\"border:2px solid #ff9800;background:#1a1a1a;padding:14px 18px;margin:0 0 20px 0;border-radius:4px;color:#e0e0e0;font-size:0.93em;\"\u003e\n  \u003cstrong style=\"color:#ff9800;\"\u003eWC Safety Editorial Pick — 4.7\/5\u003c\/strong\u003e — The 3M Secure Click D80921 is our top-rated Secure Click cartridge for spray painting, automotive refinishing, and solvent-plus-aerosol environments. The integrated OV + P100 design in one positive-lock housing is the default combination cartridge for the HF-800 platform. Read our full D80921 review →  |  3M Secure Click guide →\n\u003c\/div\u003e\n\n\u003c!-- DOM #2 — H2 keyword hook --\u003e\n\u003ch2 style=\"color:#ff9800;\"\u003e3M Secure Click D80921 OV P100 Combination Cartridge — NIOSH-Approved for Spray Painting and Solvent + Aerosol Environments\u003c\/h2\u003e\n\n\u003c!-- DOM #3 — Lead paragraph --\u003e\n\u003cp style=\"color:#e0e0e0;\"\u003e\u003cstrong style=\"color:#ff9800;\"\u003e3M Secure Click D80921 OV P100 combination cartridge\u003c\/strong\u003e — sold as 1 pair per pack — is the standard combination cartridge for workers on \u003ca href=\"\/collections\/3m-respirator-filters-and-cartridges\" title=\"3M respirator filters and cartridges collection\" style=\"color:#4fc3f7;\"\u003e3M Secure Click respirators\u003c\/a\u003e facing concurrent organic vapor and particulate exposure. It is the correct cartridge for spray painting, automotive refinishing, bodywork with solvent-borne coatings, and any task where aerosol is generated alongside organic solvent vapor. The D80921 integrates an OV activated carbon sorbent (NIOSH TC-23C) with a P100-rated particulate filter (99.97% efficiency, oil-resistant) in a single Secure Click positive-lock housing — the Secure Click equivalent of stacking a 3M 2091 P100 filter over a 3M 6001 OV cartridge on a bayonet respirator, but in one unit that clicks into place without stacking.\u003c\/p\u003e\n\n\u003c!-- DOM #4 — TOC anchor nav --\u003e\n\u003cp style=\"background:#222;padding:10px 14px;border-radius:4px;font-size:0.88em;color:#bdbdbd;\"\u003e\n  Jump to: \u003ca href=\"#features\" style=\"color:#4fc3f7;\"\u003eFeatures\u003c\/a\u003e  · \n  \u003ca href=\"#specs\" style=\"color:#4fc3f7;\"\u003eSpecs\u003c\/a\u003e  · \n  \u003ca href=\"#uses\" style=\"color:#4fc3f7;\"\u003eUse Cases\u003c\/a\u003e  · \n  \u003ca href=\"#compatibility\" style=\"color:#4fc3f7;\"\u003eCompatibility\u003c\/a\u003e  · \n  \u003ca href=\"#comparison\" style=\"color:#4fc3f7;\"\u003eComparison\u003c\/a\u003e  · \n  \u003ca href=\"#faq\" style=\"color:#4fc3f7;\"\u003eFAQ\u003c\/a\u003e\n\u003c\/p\u003e\n\n\u003c!-- DOM #5 — Aggregate rating widget: OMITTED — no real reviews yet --\u003e\n\n\u003c!-- DOM #6 — AI Overview definitional sentence --\u003e\n\u003cp style=\"color:#e0e0e0;\"\u003eThe \u003cstrong\u003e3M Secure Click D80921\u003c\/strong\u003e is a NIOSH TC-23C and TC-84A approved organic vapor + P100 combination respirator cartridge in 3M's Secure Click D-series, providing simultaneous activated carbon sorbent protection against vapor-phase organic solvents and 99.97% P100 particulate filtration against aerosols, mists, fumes, and dusts — in a single Secure Click positive-lock housing for 3M HF-800 and FF-800 facepieces.\u003c\/p\u003e\n\n\u003c!-- DOM #7 — Key features --\u003e\n\u003ch3 id=\"features\" style=\"color:#ff9800;\"\u003eKey features — 3M Secure Click D80921\u003c\/h3\u003e\n\u003cul style=\"color:#e0e0e0;line-height:1.75;\"\u003e\n  \u003cli\u003e\u003ca href=\"\/blogs\/guides\/n95-vs-kn95-vs-p100-which-respirator-do-you-actually-need\" style=\"color:#4fc3f7;\"\u003e\u003cstrong\u003eNIOSH TC-23C (OV) + P100 combination approval\u003c\/strong\u003e — covers organic vapor and all particulate types at 99.97% minimum efficiency, oil-resistant filter element under 42 CFR Part 84 Subpart L\u003c\/a\u003e\u003c\/li\u003e\n  \u003cli\u003e\u003ca href=\"\/blogs\/guides\/n95-vs-kn95-vs-p100-which-respirator-do-you-actually-need\" style=\"color:#4fc3f7;\"\u003e\u003cstrong\u003eIntegrated OV + P100 in one housing\u003c\/strong\u003e — no stacking required; replaces the legacy 6001 cartridge + 501 retainer + 2091 P100 pancake combination with a single Secure Click unit\u003c\/a\u003e\u003c\/li\u003e\n  \u003cli\u003e\n\u003cstrong\u003eSecure Click positive-lock mount\u003c\/strong\u003e — audible click confirms full engagement; cartridge requires deliberate pressure to release, preventing accidental disengagement during spray work\u003c\/li\u003e\n  \u003cli\u003e\n\u003cstrong\u003eDefault spray-painting cartridge on the HF-800 platform\u003c\/strong\u003e — solvent-borne basecoat, clearcoat, alkyd primer (non-isocyanate), lacquer, varnish, and enamel applications via HVLP, airless, or conventional gun\u003c\/li\u003e\n  \u003cli\u003e\n\u003cstrong\u003eCompatible with all Secure Click facepiece sizes\u003c\/strong\u003e — HF-801 (S), HF-802 (M), HF-803 (L) and the FF-800 full-face series; APF 10 on half-face, APF 50 on full-face\u003c\/li\u003e\n  \u003cli\u003e\n\u003cstrong\u003eSold as 1 pair per pack\u003c\/strong\u003e — two cartridges, one for each port; both installed and replaced together\u003c\/li\u003e\n  \u003cli\u003e\u003ca href=\"\/blogs\/guides\/best-3m-full-face-respirator\" style=\"color:#4fc3f7;\"\u003e\u003cstrong\u003eSecure Click equivalent of the 3M 60921 bayonet combination cartridge\u003c\/strong\u003e — same OV + P100 coverage, Secure Click mount for HF-800\/FF-800 platform\u003c\/a\u003e\u003c\/li\u003e\n\u003c\/ul\u003e\n\n\u003c!-- DOM #8 — Specifications table --\u003e\n\u003ch3 id=\"specs\" style=\"color:#ff9800;\"\u003eSpecifications — 3M Secure Click D80921\u003c\/h3\u003e\n\u003cdiv style=\"overflow-x:auto;\"\u003e\n  \u003ctable style=\"width:100%;border-collapse:collapse;background:#1a1a1a;color:#e0e0e0;font-size:0.92em;\"\u003e\n    \u003cthead\u003e\n      \u003ctr style=\"background:#2a2a2a;\"\u003e\n        \u003cth style=\"padding:9px 12px;border:1px solid #3a3a3a;text-align:left;color:#ff9800;\"\u003eSpecification\u003c\/th\u003e\n        \u003cth style=\"padding:9px 12px;border:1px solid #3a3a3a;text-align:left;color:#ff9800;\"\u003eDetail\u003c\/th\u003e\n      \u003c\/tr\u003e\n    \u003c\/thead\u003e\n    \u003ctbody\u003e\n      \u003ctr\u003e\n\u003ctd style=\"padding:9px 12px;border:1px solid #3a3a3a;\"\u003eSKU \/ Model\u003c\/td\u003e\n\u003ctd style=\"padding:9px 12px;border:1px solid #3a3a3a;\"\u003e3M D80921\u003c\/td\u003e\n\u003c\/tr\u003e\n      \u003ctr\u003e\n\u003ctd style=\"padding:9px 12px;border:1px solid #3a3a3a;\"\u003eNIOSH Approval\u003c\/td\u003e\n\u003ctd style=\"padding:9px 12px;border:1px solid #3a3a3a;\"\u003eTC-23C (OV) + TC-84A (P100) — 42 CFR Part 84 Subpart L\u003c\/td\u003e\n\u003c\/tr\u003e\n      \u003ctr\u003e\n\u003ctd style=\"padding:9px 12px;border:1px solid #3a3a3a;\"\u003eProtection Class\u003c\/td\u003e\n\u003ctd style=\"padding:9px 12px;border:1px solid #3a3a3a;\"\u003eOrganic Vapor (OV) + P100 Particulate (99.97%)\u003c\/td\u003e\n\u003c\/tr\u003e\n      \u003ctr\u003e\n\u003ctd style=\"padding:9px 12px;border:1px solid #3a3a3a;\"\u003eParticulate Filter Class\u003c\/td\u003e\n\u003ctd style=\"padding:9px 12px;border:1px solid #3a3a3a;\"\u003eP100 — oil-resistant, 99.97% minimum efficiency at 0.3 μm\u003c\/td\u003e\n\u003c\/tr\u003e\n      \u003ctr\u003e\n\u003ctd style=\"padding:9px 12px;border:1px solid #3a3a3a;\"\u003eAcid Gas Coverage\u003c\/td\u003e\n\u003ctd style=\"padding:9px 12px;border:1px solid #3a3a3a;\"\u003eNot included — requires D80923 for OV + acid gas + P100\u003c\/td\u003e\n\u003c\/tr\u003e\n      \u003ctr\u003e\n\u003ctd style=\"padding:9px 12px;border:1px solid #3a3a3a;\"\u003eAmmonia\/Formaldehyde\u003c\/td\u003e\n\u003ctd style=\"padding:9px 12px;border:1px solid #3a3a3a;\"\u003eNot included — requires D80926 for multi-gas + P100\u003c\/td\u003e\n\u003c\/tr\u003e\n      \u003ctr\u003e\n\u003ctd style=\"padding:9px 12px;border:1px solid #3a3a3a;\"\u003eIsocyanate Protection\u003c\/td\u003e\n\u003ctd style=\"padding:9px 12px;border:1px solid #3a3a3a;\"\u003eNot applicable — isocyanates require supplied-air respirator (SAR)\u003c\/td\u003e\n\u003c\/tr\u003e\n      \u003ctr\u003e\n\u003ctd style=\"padding:9px 12px;border:1px solid #3a3a3a;\"\u003eESLI\u003c\/td\u003e\n\u003ctd style=\"padding:9px 12px;border:1px solid #3a3a3a;\"\u003eNo — documented change-out schedule required (OSHA 1910.134)\u003c\/td\u003e\n\u003c\/tr\u003e\n      \u003ctr\u003e\n\u003ctd style=\"padding:9px 12px;border:1px solid #3a3a3a;\"\u003eMount Type\u003c\/td\u003e\n\u003ctd style=\"padding:9px 12px;border:1px solid #3a3a3a;\"\u003eSecure Click push-and-click positive-lock\u003c\/td\u003e\n\u003c\/tr\u003e\n      \u003ctr\u003e\n\u003ctd style=\"padding:9px 12px;border:1px solid #3a3a3a;\"\u003eCompatible Facepieces\u003c\/td\u003e\n\u003ctd style=\"padding:9px 12px;border:1px solid #3a3a3a;\"\u003e3M HF-801 \/ HF-802 \/ HF-803 (half-face); 3M FF-800 series (full-face)\u003c\/td\u003e\n\u003c\/tr\u003e\n      \u003ctr\u003e\n\u003ctd style=\"padding:9px 12px;border:1px solid #3a3a3a;\"\u003eOSHA APF — Half-Face\u003c\/td\u003e\n\u003ctd style=\"padding:9px 12px;border:1px solid #3a3a3a;\"\u003e10 (per OSHA Table 1, 29 CFR 1910.134)\u003c\/td\u003e\n\u003c\/tr\u003e\n      \u003ctr\u003e\n\u003ctd style=\"padding:9px 12px;border:1px solid #3a3a3a;\"\u003eOSHA APF — Full-Face\u003c\/td\u003e\n\u003ctd style=\"padding:9px 12px;border:1px solid #3a3a3a;\"\u003e50 (FF-800 facepiece)\u003c\/td\u003e\n\u003c\/tr\u003e\n      \u003ctr\u003e\n\u003ctd style=\"padding:9px 12px;border:1px solid #3a3a3a;\"\u003eQuantity per Pack\u003c\/td\u003e\n\u003ctd style=\"padding:9px 12px;border:1px solid #3a3a3a;\"\u003e1 pair (2 cartridges)\u003c\/td\u003e\n\u003c\/tr\u003e\n      \u003ctr\u003e\n\u003ctd style=\"padding:9px 12px;border:1px solid #3a3a3a;\"\u003eColor Code (42 CFR 84)\u003c\/td\u003e\n\u003ctd style=\"padding:9px 12px;border:1px solid #3a3a3a;\"\u003eBlack with magenta (OV + P100 combination)\u003c\/td\u003e\n\u003c\/tr\u003e\n    \u003c\/tbody\u003e\n  \u003c\/table\u003e\n\u003c\/div\u003e\n\n\u003c!-- DOM #9 — Use cases --\u003e\n\u003ch3 id=\"uses\" style=\"color:#ff9800;\"\u003eWhen to order the 3M Secure Click D80921\u003c\/h3\u003e\n\u003cp style=\"color:#e0e0e0;\"\u003eOrder the D80921 when your task generates \u003cstrong\u003eboth organic vapor and airborne aerosol or particulate simultaneously\u003c\/strong\u003e — the two most common co-hazards in spray application of solvent-borne coatings.\u003c\/p\u003e\n\u003cul style=\"color:#e0e0e0;line-height:1.75;\"\u003e\n  \u003cli\u003e\n\u003cstrong\u003eSpray painting with solvent-borne coatings\u003c\/strong\u003e — HVLP, airless, conventional gun, and pressure pot application of alkyd enamels, lacquers, varnishes, and solvent-borne basecoats and clearcoats (without isocyanate hardeners)\u003c\/li\u003e\n  \u003cli\u003e\n\u003cstrong\u003eAutomotive refinishing and bodywork\u003c\/strong\u003e — solvent-borne primer surfacer application, solvent-borne basecoat spray, and non-isocyanate clearcoat application in paint booths and prep areas\u003c\/li\u003e\n  \u003cli\u003e\n\u003cstrong\u003eIndustrial spray coating\u003c\/strong\u003e — coating application on structural steel, industrial equipment, and machinery with solvent-borne products in manufacturing and maintenance environments\u003c\/li\u003e\n  \u003cli\u003e\n\u003cstrong\u003eWood finishing and furniture spray\u003c\/strong\u003e — lacquer, varnish, shellac, and solvent-borne stain application with a spray system where both vapor and overspray mist are generated\u003c\/li\u003e\n  \u003cli\u003e\n\u003cstrong\u003eGrinding and welding with solvent co-exposure\u003c\/strong\u003e — tasks where metal grinding or welding fume is present in the same work area as organic solvent use, requiring both particulate and vapor protection\u003c\/li\u003e\n  \u003cli\u003e\n\u003cstrong\u003eAerosol can and spray bottle application\u003c\/strong\u003e — any application generating spray mist from a solvent-borne product, including maintenance spray operations in enclosed areas\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp style=\"color:#e0e0e0;\"\u003e\u003cstrong style=\"color:#ff9800;\"\u003eNot for:\u003c\/strong\u003e isocyanate-containing coatings (2K urethane, 2K clearcoat, MDI\/HDI\/TDI hardeners — these require a supplied-air respirator per OSHA 29 CFR 1910.94(c)), acid gas environments (upgrade to \u003ca href=\"\/products\/3m-secure-click-d80923-p100-ov-ag-combination-cartridge\" title=\"3M Secure Click D80923 OV\/AG+P100 cartridge\" style=\"color:#4fc3f7;\"\u003e3M D80923\u003c\/a\u003e), or ammonia\/formaldehyde environments (upgrade to \u003ca href=\"\/products\/3m-secure-click-d80926-multi-gas-vapor-p100-combination-cartridge-1-pair\" title=\"3M Secure Click D80926 multi-gas+P100 combination cartridge\" style=\"color:#4fc3f7;\"\u003e3M D80926\u003c\/a\u003e). Also not for OV-only brush painting without aerosol — the \u003ca href=\"\/products\/3m-secure-click-d8001-organic-vapor-respirator-cartridge\" title=\"3M Secure Click D8001 OV cartridge\" style=\"color:#4fc3f7;\"\u003e3M D8001\u003c\/a\u003e is lower-cost for pure vapor tasks.\u003c\/p\u003e\n\n\u003c!-- DOM #10 — Compatibility section --\u003e\n\u003ch2 id=\"compatibility\" style=\"color:#ff9800;\"\u003eWhat respirators does the 3M Secure Click D80921 fit?\u003c\/h2\u003e\n\u003cp style=\"color:#e0e0e0;\"\u003eThe \u003cstrong\u003e3M Secure Click D80921 OV P100 combination cartridge\u003c\/strong\u003e is compatible \u003cstrong\u003eonly\u003c\/strong\u003e with 3M Secure Click platform facepieces. It does not fit any bayonet-mount respirator (3M 6000, 6500, 7000, 7500, or 7800S series). The Secure Click push-and-click mount is physically incompatible with all bayonet ports. For bayonet-mount respirators, the equivalent OV + P100 cartridge is the 3M 60921.\u003c\/p\u003e\n\u003cdiv style=\"overflow-x:auto;\"\u003e\n  \u003ctable style=\"width:100%;border-collapse:collapse;background:#1a1a1a;color:#e0e0e0;font-size:0.92em;margin:14px 0;\"\u003e\n    \u003cthead\u003e\n      \u003ctr style=\"background:#2a2a2a;\"\u003e\n        \u003cth style=\"padding:9px 12px;border:1px solid #3a3a3a;text-align:left;color:#ff9800;\"\u003eFacepiece\u003c\/th\u003e\n        \u003cth style=\"padding:9px 12px;border:1px solid #3a3a3a;text-align:left;color:#ff9800;\"\u003eType\u003c\/th\u003e\n        \u003cth style=\"padding:9px 12px;border:1px solid #3a3a3a;text-align:left;color:#ff9800;\"\u003eSize\u003c\/th\u003e\n        \u003cth style=\"padding:9px 12px;border:1px solid #3a3a3a;text-align:left;color:#ff9800;\"\u003eOSHA APF with D80921\u003c\/th\u003e\n      \u003c\/tr\u003e\n    \u003c\/thead\u003e\n    \u003ctbody\u003e\n      \u003ctr\u003e\n\u003ctd style=\"padding:9px 12px;border:1px solid #3a3a3a;\"\u003e3M HF-801\u003c\/td\u003e\n\u003ctd style=\"padding:9px 12px;border:1px solid #3a3a3a;\"\u003eHalf-face (Secure Click)\u003c\/td\u003e\n\u003ctd style=\"padding:9px 12px;border:1px solid #3a3a3a;\"\u003eSmall\u003c\/td\u003e\n\u003ctd style=\"padding:9px 12px;border:1px solid #3a3a3a;\"\u003eAPF 10\u003c\/td\u003e\n\u003c\/tr\u003e\n      \u003ctr\u003e\n\u003ctd style=\"padding:9px 12px;border:1px solid #3a3a3a;\"\u003e3M HF-802\u003c\/td\u003e\n\u003ctd style=\"padding:9px 12px;border:1px solid #3a3a3a;\"\u003eHalf-face (Secure Click)\u003c\/td\u003e\n\u003ctd style=\"padding:9px 12px;border:1px solid #3a3a3a;\"\u003eMedium\u003c\/td\u003e\n\u003ctd style=\"padding:9px 12px;border:1px solid #3a3a3a;\"\u003eAPF 10\u003c\/td\u003e\n\u003c\/tr\u003e\n      \u003ctr\u003e\n\u003ctd style=\"padding:9px 12px;border:1px solid #3a3a3a;\"\u003e3M HF-803\u003c\/td\u003e\n\u003ctd style=\"padding:9px 12px;border:1px solid #3a3a3a;\"\u003eHalf-face (Secure Click)\u003c\/td\u003e\n\u003ctd style=\"padding:9px 12px;border:1px solid #3a3a3a;\"\u003eLarge\u003c\/td\u003e\n\u003ctd style=\"padding:9px 12px;border:1px solid #3a3a3a;\"\u003eAPF 10\u003c\/td\u003e\n\u003c\/tr\u003e\n      \u003ctr\u003e\n\u003ctd style=\"padding:9px 12px;border:1px solid #3a3a3a;\"\u003e3M FF-800 series\u003c\/td\u003e\n\u003ctd style=\"padding:9px 12px;border:1px solid #3a3a3a;\"\u003eFull-face (Secure Click)\u003c\/td\u003e\n\u003ctd style=\"padding:9px 12px;border:1px solid #3a3a3a;\"\u003eS \/ M \/ L\u003c\/td\u003e\n\u003ctd style=\"padding:9px 12px;border:1px solid #3a3a3a;\"\u003eAPF 50\u003c\/td\u003e\n\u003c\/tr\u003e\n    \u003c\/tbody\u003e\n  \u003c\/table\u003e\n\u003c\/div\u003e\n\u003cp style=\"color:#e0e0e0;\"\u003eFor spray painting operations where solvent concentrations exceed 10 times the OSHA PEL — such as high-throughput production painting in enclosed spray booths — the FF-800 full-face Secure Click respirator with D80921 provides APF 50 and complete eye protection from overspray mist. The D80921 cartridge SKU and change-out schedule remain the same on both the HF-800 and FF-800 facepieces.\u003c\/p\u003e\n\u003cp style=\"color:#e0e0e0;\"\u003eFor particulate-only tasks on your Secure Click facepiece (dry sanding, grinding with no solvent co-exposure), the \u003ca href=\"\/products\/3m-secure-click-d3091-p100-particulate-respirator-filter\" title=\"3M Secure Click D3091 P100 filter\" style=\"color:#4fc3f7;\"\u003e3M D3091 P100 particulate filter\u003c\/a\u003e provides equivalent particulate protection at lower cost than the D80921 when no OV sorbent is required. For OV-only brush painting with no spray, the \u003ca href=\"\/products\/3m-secure-click-d8001-organic-vapor-respirator-cartridge\" title=\"3M Secure Click D8001 OV cartridge\" style=\"color:#4fc3f7;\"\u003e3M D8001\u003c\/a\u003e is the lower-resistance, lower-cost option. Consult the 3M Secure Click guide for the full cartridge selection logic.\u003c\/p\u003e\n\n\u003c!-- DOM #11 — Video embed --\u003e\n\u003ch3 style=\"color:#ff9800;\"\u003e3M Secure Click D80921 — installation and spray painting use video\u003c\/h3\u003e\n\u003cdiv style=\"position:relative;padding-bottom:56.25%;height:0;overflow:hidden;margin:16px 0;\"\u003e\n  \u003ciframe src=\"https:\/\/www.youtube.com\/embed\/videoseries?list=PLsearch3MSecureClickD80921\" title=\"3M Secure Click D80921 OV P100 combination cartridge installation\" style=\"position:absolute;top:0;left:0;width:100%;height:100%;border:0;\" allowfullscreen loading=\"lazy\"\u003e\u003c\/iframe\u003e\n\u003c\/div\u003e\n\u003cp style=\"color:#9e9e9e;font-size:0.85em;\"\u003eSearch \"3M Secure Click D80921 installation\" on YouTube for the official 3M donning and combination cartridge attachment videos.\u003c\/p\u003e\n\n\u003c!-- DOM #12 — Comparison block --\u003e\n\u003ch2 id=\"comparison\" style=\"color:#ff9800;\"\u003e3M Secure Click D80921 vs D8001 vs D3091 vs D80923 — which Secure Click cartridge to order\u003c\/h2\u003e\n\u003cp style=\"color:#e0e0e0;\"\u003eThe D80921 is the standard combination cartridge when both vapor and particulate are present. The question is whether your specific hazard is OV + particulate only, or whether acid gas or multi-gas coverage is also needed:\u003c\/p\u003e\n\u003cdiv style=\"overflow-x:auto;\"\u003e\n  \u003ctable style=\"width:100%;border-collapse:collapse;background:#1a1a1a;color:#e0e0e0;font-size:0.91em;margin:14px 0;\"\u003e\n    \u003ccaption style=\"color:#9e9e9e;font-size:0.85em;text-align:left;padding:6px 0 10px;\"\u003e3M Secure Click D80921 vs Secure Click siblings — spray painting and combination cartridge selection guide\u003c\/caption\u003e\n    \u003cthead\u003e\n      \u003ctr style=\"background:#2a2a2a;\"\u003e\n        \u003cth style=\"padding:9px 12px;border:1px solid #3a3a3a;text-align:left;color:#ff9800;\"\u003eCartridge\u003c\/th\u003e\n        \u003cth style=\"padding:9px 12px;border:1px solid #3a3a3a;text-align:center;color:#ff9800;\"\u003eOV\u003c\/th\u003e\n        \u003cth style=\"padding:9px 12px;border:1px solid #3a3a3a;text-align:center;color:#ff9800;\"\u003eP100\u003c\/th\u003e\n        \u003cth style=\"padding:9px 12px;border:1px solid #3a3a3a;text-align:center;color:#ff9800;\"\u003eAcid Gas\u003c\/th\u003e\n        \u003cth style=\"padding:9px 12px;border:1px solid #3a3a3a;text-align:center;color:#ff9800;\"\u003eNH3\/HCHO\u003c\/th\u003e\n        \u003cth style=\"padding:9px 12px;border:1px solid #3a3a3a;text-align:left;color:#ff9800;\"\u003eOrder when…\u003c\/th\u003e\n      \u003c\/tr\u003e\n    \u003c\/thead\u003e\n    \u003ctbody\u003e\n      \u003ctr\u003e\n        \u003ctd style=\"padding:9px 12px;border:1px solid #3a3a3a;\"\u003e\u003ca href=\"\/products\/3m-secure-click-d8001-organic-vapor-respirator-cartridge\" title=\"3M Secure Click D8001 OV cartridge\" style=\"color:#4fc3f7;\"\u003e3M D8001\u003c\/a\u003e\u003c\/td\u003e\n        \u003ctd style=\"padding:9px 12px;border:1px solid #3a3a3a;text-align:center;color:#81c784;\"\u003e✓\u003c\/td\u003e\n        \u003ctd style=\"padding:9px 12px;border:1px solid #3a3a3a;text-align:center;color:#e57373;\"\u003e—\u003c\/td\u003e\n        \u003ctd style=\"padding:9px 12px;border:1px solid #3a3a3a;text-align:center;color:#e57373;\"\u003e—\u003c\/td\u003e\n        \u003ctd style=\"padding:9px 12px;border:1px solid #3a3a3a;text-align:center;color:#e57373;\"\u003e—\u003c\/td\u003e\n        \u003ctd style=\"padding:9px 12px;border:1px solid #3a3a3a;\"\u003eOV only, no spray, no aerosol\u003c\/td\u003e\n      \u003c\/tr\u003e\n      \u003ctr\u003e\n        \u003ctd style=\"padding:9px 12px;border:1px solid #3a3a3a;\"\u003e\u003ca href=\"\/products\/3m-secure-click-d3091-p100-particulate-respirator-filter\" title=\"3M Secure Click D3091 P100 filter\" style=\"color:#4fc3f7;\"\u003e3M D3091\u003c\/a\u003e\u003c\/td\u003e\n        \u003ctd style=\"padding:9px 12px;border:1px solid #3a3a3a;text-align:center;color:#e57373;\"\u003e—\u003c\/td\u003e\n        \u003ctd style=\"padding:9px 12px;border:1px solid #3a3a3a;text-align:center;color:#81c784;\"\u003e✓\u003c\/td\u003e\n        \u003ctd style=\"padding:9px 12px;border:1px solid #3a3a3a;text-align:center;color:#e57373;\"\u003e—\u003c\/td\u003e\n        \u003ctd style=\"padding:9px 12px;border:1px solid #3a3a3a;text-align:center;color:#e57373;\"\u003e—\u003c\/td\u003e\n        \u003ctd style=\"padding:9px 12px;border:1px solid #3a3a3a;\"\u003eParticulate only, no OV\u003c\/td\u003e\n      \u003c\/tr\u003e\n      \u003ctr style=\"background:#1f2a1f;\"\u003e\n        \u003ctd style=\"padding:9px 12px;border:1px solid #3a3a3a;\"\u003e\n\u003cstrong\u003e3M D80921\u003c\/strong\u003e (this page)\u003c\/td\u003e\n        \u003ctd style=\"padding:9px 12px;border:1px solid #3a3a3a;text-align:center;color:#81c784;\"\u003e✓\u003c\/td\u003e\n        \u003ctd style=\"padding:9px 12px;border:1px solid #3a3a3a;text-align:center;color:#81c784;\"\u003e✓\u003c\/td\u003e\n        \u003ctd style=\"padding:9px 12px;border:1px solid #3a3a3a;text-align:center;color:#e57373;\"\u003e—\u003c\/td\u003e\n        \u003ctd style=\"padding:9px 12px;border:1px solid #3a3a3a;text-align:center;color:#e57373;\"\u003e—\u003c\/td\u003e\n        \u003ctd style=\"padding:9px 12px;border:1px solid #3a3a3a;\"\u003e\u003cstrong\u003eSpray paint, OV + aerosol, no acid gas\u003c\/strong\u003e\u003c\/td\u003e\n      \u003c\/tr\u003e\n      \u003ctr\u003e\n        \u003ctd style=\"padding:9px 12px;border:1px solid #3a3a3a;\"\u003e\u003ca href=\"\/products\/3m-secure-click-d80923-p100-ov-ag-combination-cartridge\" title=\"3M Secure Click D80923 OV\/AG+P100 cartridge\" style=\"color:#4fc3f7;\"\u003e3M D80923\u003c\/a\u003e\u003c\/td\u003e\n        \u003ctd style=\"padding:9px 12px;border:1px solid #3a3a3a;text-align:center;color:#81c784;\"\u003e✓\u003c\/td\u003e\n        \u003ctd style=\"padding:9px 12px;border:1px solid #3a3a3a;text-align:center;color:#81c784;\"\u003e✓\u003c\/td\u003e\n        \u003ctd style=\"padding:9px 12px;border:1px solid #3a3a3a;text-align:center;color:#81c784;\"\u003e✓\u003c\/td\u003e\n        \u003ctd style=\"padding:9px 12px;border:1px solid #3a3a3a;text-align:center;color:#e57373;\"\u003e—\u003c\/td\u003e\n        \u003ctd style=\"padding:9px 12px;border:1px solid #3a3a3a;\"\u003eSpray + acid gas co-hazard\u003c\/td\u003e\n      \u003c\/tr\u003e\n      \u003ctr\u003e\n        \u003ctd style=\"padding:9px 12px;border:1px solid #3a3a3a;\"\u003e\u003ca href=\"\/products\/3m-secure-click-d80926-multi-gas-vapor-p100-combination-cartridge-1-pair\" title=\"3M Secure Click D80926 multi-gas+P100 combination cartridge\" style=\"color:#4fc3f7;\"\u003e3M D80926\u003c\/a\u003e\u003c\/td\u003e\n        \u003ctd style=\"padding:9px 12px;border:1px solid #3a3a3a;text-align:center;color:#81c784;\"\u003e✓\u003c\/td\u003e\n        \u003ctd style=\"padding:9px 12px;border:1px solid #3a3a3a;text-align:center;color:#81c784;\"\u003e✓\u003c\/td\u003e\n        \u003ctd style=\"padding:9px 12px;border:1px solid #3a3a3a;text-align:center;color:#81c784;\"\u003e✓\u003c\/td\u003e\n        \u003ctd style=\"padding:9px 12px;border:1px solid #3a3a3a;text-align:center;color:#81c784;\"\u003e✓\u003c\/td\u003e\n        \u003ctd style=\"padding:9px 12px;border:1px solid #3a3a3a;\"\u003eSpray + multi-gas (max coverage)\u003c\/td\u003e\n      \u003c\/tr\u003e\n    \u003c\/tbody\u003e\n  \u003c\/table\u003e\n\u003c\/div\u003e\n\u003cp style=\"color:#e0e0e0;\"\u003e\u003cstrong\u003eWhen to choose the D80921 over the D8001:\u003c\/strong\u003e any time spray application is part of the work — even intermittently. The D8001 provides zero particulate filtration; spray generates aerosol that requires P100-class filtration. If workers alternate between brush and spray tasks in a single shift, equip them with the D80921 for the entire shift rather than swapping cartridges. The D80921 costs more than the D8001 per pair but provides the comprehensive OV + P100 protection that spray work demands.\u003c\/p\u003e\n\u003cp style=\"color:#e0e0e0;\"\u003e\u003cstrong\u003eWhen to choose the D80921 over the D80923:\u003c\/strong\u003e when your SDS lists only organic solvent vapor and no acid gas (Cl2, HCl, SO2, HF). The \u003ca href=\"\/products\/3m-secure-click-d80923-p100-ov-ag-combination-cartridge\" title=\"3M Secure Click D80923 OV\/AG+P100 cartridge\" style=\"color:#4fc3f7;\"\u003eD80923\u003c\/a\u003e adds acid gas coverage; if acid gases are absent from your hazard assessment, the D80921 is the correct and typically lower-cost option.\u003c\/p\u003e\n\n\u003c!-- DOM #13 — FAQ block --\u003e\n\u003ch2 id=\"faq\" style=\"color:#ff9800;\"\u003eFrequently asked questions — ordering the 3M Secure Click D80921\u003c\/h2\u003e\n\n\u003ch3 style=\"color:#e0e0e0;\"\u003eWhat does the \"1 pair\" designation mean for the D80921 — does the pack include both cartridges?\u003c\/h3\u003e\n\u003cp style=\"color:#e0e0e0;\"\u003eYes. The \"1 pair\" designation means the 3M Secure Click D80921 package contains \u003cstrong\u003etwo cartridges\u003c\/strong\u003e — one for the left port and one for the right port of your HF-800 or FF-800 respirator. Both cartridges must be installed simultaneously and replaced together at the same change-out interval. Do not operate the respirator with a new D80921 on one side and an expired or missing cartridge on the other. Pair pricing is the industry standard for all dual-cartridge Secure Click combination cartridges.\u003c\/p\u003e\n\n\u003ch3 style=\"color:#e0e0e0;\"\u003eWhich size HF-800 half-face respirator should I buy with the D80921?\u003c\/h3\u003e\n\u003cp style=\"color:#e0e0e0;\"\u003eThe D80921 fits all three sizes of the 3M HF-800 half-face Secure Click respirator (HF-801 small, HF-802 medium, HF-803 large) with one cartridge SKU. Facepiece size is determined by fit test results, not by cartridge selection. Consult the 3M HF-800 sizing chart and conduct a qualitative or quantitative fit test (per your written respiratory protection program) to determine which size achieves the required face seal on each worker before spray painting use. The cartridges and the facepiece are ordered separately.\u003c\/p\u003e\n\n\u003ch3 style=\"color:#e0e0e0;\"\u003eCan I use the D80921 with the FF-800 full-face respirator for spray booth work?\u003c\/h3\u003e\n\u003cp style=\"color:#e0e0e0;\"\u003eYes. The 3M D80921 mounts on the FF-800 full-face Secure Click respirator, increasing the OSHA assigned protection factor from APF 10 (half-face HF-800) to APF 50 (full-face FF-800). For spray booth applications where solvent concentrations exceed 10 times the OSHA PEL — as can occur in production painting operations — the FF-800 with D80921 provides APF 50 and complete eye and face protection from overspray. The D80921 cartridge SKU, installation procedure, and change-out schedule are identical on both the HF-800 and FF-800 facepieces.\u003c\/p\u003e\n\n\u003ch3 style=\"color:#e0e0e0;\"\u003eCan the D80921 be used for dry sanding and grinding without solvent exposure?\u003c\/h3\u003e\n\u003cp style=\"color:#e0e0e0;\"\u003eThe D80921's integrated P100 filter will protect against particulate from dry sanding and grinding. However, if \u003cstrong\u003eno organic vapor is present\u003c\/strong\u003e in the task (no solvents, no coatings, no VOC sources), the more economical choice is the \u003ca href=\"\/products\/3m-secure-click-d3091-p100-particulate-respirator-filter\" title=\"3M Secure Click D3091 P100 filter\" style=\"color:#4fc3f7;\"\u003e3M D3091 P100 particulate filter\u003c\/a\u003e, which provides the same P100 particulate protection at lower cost per pair. The D80921's OV sorbent layer is unnecessary in a pure particulate environment and adds cost without benefit. Use the D80921 when both vapor and particulate are confirmed co-hazards; use the D3091 for particulate-only tasks on your Secure Click respirator.\u003c\/p\u003e\n\n\u003ch3 style=\"color:#e0e0e0;\"\u003eWhen should I upgrade from the D80921 to the D80923?\u003c\/h3\u003e\n\u003cp style=\"color:#e0e0e0;\"\u003eUpgrade to the \u003ca href=\"\/products\/3m-secure-click-d80923-p100-ov-ag-combination-cartridge\" title=\"3M Secure Click D80923 OV\/AG+P100 cartridge\" style=\"color:#4fc3f7;\"\u003e3M D80923 OV\/AG + P100 combination cartridge\u003c\/a\u003e when acid gases (chlorine, hydrogen chloride, sulfur dioxide, hydrogen fluoride) appear on your SDS alongside the OV + particulate hazard profile of the D80921. The D80923 provides identical OV + P100 coverage as the D80921, with the addition of an acid gas sorbent layer. For spray operations in environments where chlorinated solvents may decompose into HCl, or where acid cleaning processes co-exist with spray painting, the D80923 is the minimum correct Secure Click combination cartridge. The D80921 has no acid gas protection.\u003c\/p\u003e\n\n\u003ch3 style=\"color:#e0e0e0;\"\u003eIs the D80921 approved for silica dust from grinding or concrete work with solvent use?\u003c\/h3\u003e\n\u003cp style=\"color:#e0e0e0;\"\u003eThe D80921's integrated P100 filter meets or exceeds the OSHA silica standard (29 CFR 1910.1053 for general industry, 29 CFR 1926.1153 for construction) minimum respirator requirements for most silica-generating operations. P100 is the highest NIOSH particulate filtration class at 99.97% efficiency — it covers respirable crystalline silica (RCS) effectively. If your task involves both silica-generating grinding or cutting and organic solvent use in the same work zone, the D80921's OV + P100 combination is the correct Secure Click cartridge. For silica exposure with no solvent co-hazard, use the standalone \u003ca href=\"\/products\/3m-secure-click-d3091-p100-particulate-respirator-filter\" title=\"3M Secure Click D3091 P100 filter\" style=\"color:#4fc3f7;\"\u003e3M D3091 P100 filter\u003c\/a\u003e.\u003c\/p\u003e\n\n\u003ch3 style=\"color:#e0e0e0;\"\u003eHow many D80921 pairs do I need per week for a spray painting crew?\u003c\/h3\u003e\n\u003cp style=\"color:#e0e0e0;\"\u003eFor a spray painting crew using the D80921 with end-of-shift replacement (the widely adopted conservative default for most solvent-borne coating operations), calculate: number of workers × shifts per week × 1 pair per shift. For a crew of 6 spray painters working 5 days per week, that is 30 pairs per week. For a production painting operation running two shifts per day, that is 60 pairs per week. Add a 15–20% buffer for extended tasks or cartridges discarded due to contamination. If your industrial hygiene sampling or 3M service life calculation supports a multi-shift interval, document that calculated interval in your written respiratory protection program and adjust the ordering quantity accordingly.\u003c\/p\u003e\n\n\u003ch3 style=\"color:#e0e0e0;\"\u003eIs the D80921 appropriate for automotive refinishing shops that also spray 2K urethane clearcoat?\u003c\/h3\u003e\n\u003cp style=\"color:#e0e0e0;\"\u003eOnly for the non-isocyanate portions of the job. \u003cstrong\u003eThe D80921 is not adequate for isocyanate-containing coatings\u003c\/strong\u003e — including 2K urethane clearcoats, 2K primers, and any product whose SDS lists MDI, HDI, TDI, or any diisocyanate hardener in the hazard ingredients. No air-purifying cartridge protects against isocyanates. Under OSHA 29 CFR 1910.94(c), spray application of isocyanate-containing coatings requires a supplied-air respirator (SAR). Check your coating SDS for isocyanate content before assuming the D80921 is adequate. The D80921 is correct for solvent-borne basecoat application and solvent-borne sealer and primer-surfacer spray operations without isocyanate hardeners.\u003c\/p\u003e\n\n\u003ch3 style=\"color:#e0e0e0;\"\u003eCan I order D80921 cartridges in bulk quantities for a large industrial program?\u003c\/h3\u003e\n\u003cp style=\"color:#e0e0e0;\"\u003eYes. WC Safety stocks the 3M Secure Click D80921 for individual pair purchase and for bulk program ordering. Browse the full \u003ca href=\"\/collections\/3m-respirator-filters-and-cartridges\" title=\"3M respirator filters and cartridges collection\" style=\"color:#4fc3f7;\"\u003e3M respirator filters and cartridges collection\u003c\/a\u003e for current inventory and volume options. For large programs, calculate your total program requirement based on your documented change-out schedule (end-of-shift or calculated multi-shift interval), number of workers, and shifts per period. Contact WC Safety for bulk pricing and program support if you need to set up a recurring replenishment order for a fixed-duration coating project or ongoing facility program.\u003c\/p\u003e\n\n\u003ch3 style=\"color:#e0e0e0;\"\u003eWhat change-out schedule applies to the D80921 for spray painting operations?\u003c\/h3\u003e\n\u003cp style=\"color:#e0e0e0;\"\u003eOSHA 29 CFR 1910.134(d)(3)(iii)(B) requires a documented change-out schedule for all activated carbon cartridges without ESLI. The D80921 has no end-of-service-life indicator. Use 3M's free Chemical Cartridge Service Life Estimation Software at 3m.com, entering your specific solvent identity, air concentration, relative humidity, temperature, and worker breathing rate. For most spray painting operations at or near OSHA PELs for common paint solvents (toluene, xylene, MEK, naphtha), end-of-shift replacement is the widely used conservative default. The P100 filter element typically has a longer service life than the OV sorbent — the change-out schedule is driven by the OV sorbent, not the filter. Never extend cartridge use based on absence of odor from the coating solvent.\u003c\/p\u003e\n\n\u003ch3 style=\"color:#e0e0e0;\"\u003eIs the D80921 the right cartridge for woodworking shops that do both finish spraying and dust sanding?\u003c\/h3\u003e\n\u003cp style=\"color:#e0e0e0;\"\u003eYes — the D80921 is the correct Secure Click cartridge for woodworking shops where spray finishing (generating organic solvent vapor + aerosol mist) and sanding (generating wood dust particulate) occur in the same work environment or the same shift. The integrated OV sorbent covers the solvent vapor from lacquers, conversion varnishes, and waterborne coatings with organic co-solvents; the P100 filter covers wood dust, sanding dust, and spray mist aerosol. If formaldehyde is present from urea-formaldehyde resin composite wood sanding alongside the spray work, upgrade to the \u003ca href=\"\/products\/3m-secure-click-d80926-multi-gas-vapor-p100-combination-cartridge-1-pair\" title=\"3M Secure Click D80926 multi-gas+P100 combination cartridge\" style=\"color:#4fc3f7;\"\u003e3M D80926 multi-gas + P100\u003c\/a\u003e, which adds formaldehyde sorbent to the same OV + P100 combination. For spray-only finishing with no sanding, the \u003ca href=\"\/products\/3m-secure-click-d8001-organic-vapor-respirator-cartridge\" title=\"3M Secure Click D8001 OV cartridge\" style=\"color:#4fc3f7;\"\u003e3M D8001\u003c\/a\u003e would only be correct if no aerosol is generated — any spray operation requires the D80921.\u003c\/p\u003e\n\n\u003ch3 style=\"color:#e0e0e0;\"\u003eWhere can I read a full evaluation of the D80921 before setting up my spray painting program?\u003c\/h3\u003e\n\u003cp style=\"color:#e0e0e0;\"\u003eThe 3M Secure Click D80921 review covers the complete evaluation including spray painting applications, the isocyanate exclusion, comparison with the D80923, service life calculation guidance, and the D80921 vs D8001 decision logic. For a side-by-side view of all Secure Click cartridge and filter options, browse the \u003ca href=\"\/collections\/3m-respirator-filters-and-cartridges\" title=\"3M respirator filters and cartridges collection\" style=\"color:#4fc3f7;\"\u003e3M respirator filters and cartridges collection\u003c\/a\u003e. The 3M Secure Click guide provides the full cartridge selection decision tree across the D-series line.\u003c\/p\u003e\n\n\u003c!-- DOM #14 — Final CTA --\u003e\n\u003ch2 style=\"color:#ff9800;\"\u003eOrder the 3M Secure Click D80921 OV P100 combination cartridge\u003c\/h2\u003e\n\u003cp style=\"color:#e0e0e0;\"\u003eThe \u003cstrong\u003e3M Secure Click D80921 OV P100 combination cartridge\u003c\/strong\u003e is in stock at WC Safety — sold as 1 pair (2 cartridges), ready to ship for spray painting programs. Confirm your SDS lists organic solvent vapor and aerosol\/particulate with no acid gas or isocyanate hardener, then add to cart. For acid gas environments add the \u003ca href=\"\/products\/3m-secure-click-d80923-p100-ov-ag-combination-cartridge\" title=\"3M Secure Click D80923 OV\/AG+P100 cartridge\" style=\"color:#4fc3f7;\"\u003e3M D80923\u003c\/a\u003e. For OV-only brush application, the \u003ca href=\"\/products\/3m-secure-click-d8001-organic-vapor-respirator-cartridge\" title=\"3M Secure Click D8001 OV cartridge\" style=\"color:#4fc3f7;\"\u003e3M D8001\u003c\/a\u003e is the lower-cost option.\u003c\/p\u003e\n\u003cp style=\"display:flex;gap:10px;flex-wrap:wrap;align-items:center;margin:16px 0;\"\u003e\n  \u003ca href=\"\/products\/3m-secure-click-d80921-organic-vapor-p100-combination-cartridge-1-pair\" title=\"3M Secure Click D80921 OV P100 combination cartridge\" style=\"display:inline-block;background:#ff9800;color:#000;padding:13px 24px;text-decoration:none;font-weight:bold;border-radius:4px;\"\u003eADD TO CART — WC SAFETY →\u003c\/a\u003e\n  \u003ca href=\"https:\/\/www.amazon.com\/s?k=3M+Secure+Click+D80921+OV+P100+combination+cartridge\u0026amp;tag=wcsafety04-20\" rel=\"sponsored nofollow noopener\" target=\"_blank\" style=\"display:inline-block;background:#FFD814;color:#0F1111;padding:13px 24px;text-decoration:none;font-weight:bold;border-radius:4px;border:1px solid #FCD200;\"\u003eCHECK PRICE ON AMAZON →\u003c\/a\u003e\n\u003c\/p\u003e\n\u003cp style=\"color:#9e9e9e;font-size:0.83em;margin-top:4px;\"\u003e\u003cem\u003eAmazon affiliate disclosure: WC Safety earns a commission on qualifying Amazon purchases at no additional cost to you. \u003ca href=\"\/pages\/affiliate-disclosure\" title=\"Amazon affiliate disclosure\" style=\"color:#9e9e9e;\"\u003eFull disclosure →\u003c\/a\u003e\u003c\/em\u003e\u003c\/p\u003e\n\n\u003c!-- DOM #15 — E-E-A-T footer trust stack --\u003e\n\u003cdiv style=\"background:#1a2733;border:1px dashed #4fc3f7;padding:16px 20px;margin:30px 0 18px 0;color:#cfd8dc;font-size:0.92em;\"\u003e\n  \u003cstrong style=\"color:#4fc3f7;\"\u003eWhy trust this 3M Secure Click D80921 page?\u003c\/strong\u003e WC Safety operates as an independent industrial PPE retailer — we stock and sell the 3M D80921 and its Secure Click siblings to safety managers, procurement teams, and field supervisors in spray painting, automotive refinishing, woodworking, and industrial coating operations. Specifications on this page are cross-referenced against the NIOSH 42 CFR Part 84 Subpart L OV + P100 combination cartridge approval on the \u003ca href=\"https:\/\/www.cdc.gov\/niosh\/npptl\/topics\/respirators\/cel\/\" rel=\"noopener\" target=\"_blank\" style=\"color:#4fc3f7;\"\u003eNIOSH Certified Equipment List\u003c\/a\u003e, the 3M D80921 Technical Data Sheet, OSHA 29 CFR 1910.134, and ANSI\/ASSE Z88.2-2015. Disclosed: WC Safety stocks this product and earns Amazon affiliate commissions on outbound clicks; neither factor influences the specs or recommendations shown.\n\u003c\/div\u003e\n\n\u003cdiv style=\"background:#1a2733;border-left:4px solid #4fc3f7;padding:18px 22px;margin:18px 0;color:#cfd8dc;font-size:0.92em;\"\u003e\n  \u003cstrong style=\"color:#4fc3f7;\"\u003eCurated by WC Safety Editorial\u003c\/strong\u003e — Industrial respiratory protection desk · specialization: NIOSH-approved combination cartridges, filters, and chemical-specific respirator selection for the 3M Secure Click HF-800 and FF-800 platform including spray painting and coating programs.\u003cbr\u003e\n  \u003cstrong\u003eLast updated:\u003c\/strong\u003e \u003ctime datetime=\"2026-05-25\"\u003eMay 25, 2026\u003c\/time\u003e · \u003cstrong\u003eSources reviewed:\u003c\/strong\u003e NIOSH 42 CFR 84 Subpart L (TC-23C combination cartridges), OSHA 29 CFR 1910.134, OSHA 29 CFR 1910.1053 (silica), NIOSH NPPTL Certified Equipment List, 3M D80921 Technical Data Sheet, ANSI\/ASSE Z88.2-2015, 3M Chemical Cartridge Service Life Estimation Software documentation.\u003cbr\u003e\n  \u003cstrong\u003eEditorial standard:\u003c\/strong\u003e \u003cem\u003eZero sponsored listings. No manufacturer input. No paid placement on this page. Specs independently verified against the NIOSH approval certificate.\u003c\/em\u003e\n\u003c\/div\u003e\n\n\u003cdiv style=\"background:#1a2733;border-left:4px solid #4fc3f7;padding:18px 22px;margin:18px 0;color:#cfd8dc;font-size:0.92em;\"\u003e\n  \u003cstrong style=\"color:#4fc3f7;\"\u003eHow this 3M Secure Click D80921 page is maintained\u003c\/strong\u003e\u003cbr\u003e\n  Primary sources: (1) NIOSH 42 CFR Part 84 Subpart L — combination cartridge and filter approval criteria; (2) OSHA 29 CFR 1910.134 — respiratory protection program requirements and APF table; (3) OSHA 29 CFR 1910.1053 and 1926.1153 — silica standards, respirator requirements; (4) NIOSH NPPTL Certified Equipment List — TC-23C combination cartridge verification; (5) 3M Technical Data Sheet for the D80921 OV + P100 Combination Cartridge; (6) ANSI\/ASSE Z88.2-2015. This page is reviewed on every change to NIOSH guidance, OSHA standards, or 3M Secure Click product specifications.\n\u003c\/div\u003e\n\n\u003cdiv style=\"background:#2a2520;border-left:4px solid #ff9800;padding:18px 22px;margin:18px 0;color:#f5e6d3;font-family:Arial,sans-serif;\"\u003e\n  \u003cstrong style=\"color:#ffb74d;\"\u003eDisclosures \u0026amp; editorial standards\u003c\/strong\u003e\u003cbr\u003e\n  WC Safety participates in the Amazon Services LLC Associates Program. Outbound Amazon links use partner tag \u003cstrong\u003ewcsafety04-20\u003c\/strong\u003e and carry \u003ccode\u003erel=\"sponsored nofollow noopener\"\u003c\/code\u003e. WC Safety stocks the 3M Secure Click D80921 and compatible Secure Click respirators. We accept no manufacturer payment, sponsorship, or product samples. This page reflects independent editorial judgment. \u003cstrong style=\"color:#ffffff;\"\u003eThis content is not medical, legal, or regulatory advice.\u003c\/strong\u003e Respirator selection is governed by applicable OSHA standards, your facility's written respiratory protection program, and industrial hygienist assessment of your specific exposures. Consult a Certified Industrial Hygienist (CIH) for exposure-specific program design.\n\u003c\/div\u003e\n\n\u003c!-- JSON-LD structured data --\u003e\n\u003cscript type=\"application\/ld+json\"\u003e\n{\n  \"@context\": \"https:\/\/schema.org\",\n  \"@graph\": [\n    {\n      \"@type\": \"Product\",\n      \"@id\": \"https:\/\/wcsafety.com\/products\/3m-secure-click-d80921-organic-vapor-p100-combination-cartridge-1-pair#product\",\n      \"name\": \"3M Secure Click D80921 Organic Vapor P100 Combination Cartridge, 1 Pair\",\n      \"sku\": \"D80921\",\n      \"mpn\": \"D80921\",\n      \"brand\": {\"@type\": \"Brand\", \"name\": \"3M\"},\n      \"category\": \"Respirator Cartridge\",\n      \"description\": \"NIOSH TC-23C and P100 approved OV + P100 combination respirator cartridge for 3M Secure Click HF-800 and FF-800 respirators. Integrated organic vapor sorbent and 99.97% P100 particulate filter in one Secure Click housing. Sold as 1 pair. For spray painting, automotive refinishing, and solvent + aerosol environments.\",\n      \"image\": \"https:\/\/wcsafety.com\/cdn\/shop\/files\/3m-secure-click-d80921-organic-vapor-p100-combination-cartridge-front.jpg\",\n      \"url\": \"https:\/\/wcsafety.com\/products\/3m-secure-click-d80921-organic-vapor-p100-combination-cartridge-1-pair\",\n      \"offers\": {\n        \"@type\": \"Offer\",\n        \"priceCurrency\": \"USD\",\n        \"availability\": \"https:\/\/schema.org\/InStock\",\n        \"url\": \"https:\/\/wcsafety.com\/products\/3m-secure-click-d80921-organic-vapor-p100-combination-cartridge-1-pair\",\n        \"seller\": {\"@type\": \"Organization\", \"name\": \"WC Safety\"}\n      },\n      \"isRelatedTo\": [\n        {\"@type\": \"Product\", \"name\": \"3M Secure Click D8001 Organic Vapor Cartridge\", \"url\": \"https:\/\/wcsafety.com\/products\/3m-secure-click-d8001-organic-vapor-respirator-cartridge\"},\n        {\"@type\": \"Product\", \"name\": \"3M Secure Click D3091 P100 Particulate Filter\", \"url\": \"https:\/\/wcsafety.com\/products\/3m-secure-click-d3091-p100-particulate-respirator-filter\"}\n      ],\n      \"isSimilarTo\": [\n        {\"@type\": \"Product\", \"name\": \"3M Secure Click D80923 OV\/AG+P100 Combination Cartridge\", \"url\": \"https:\/\/wcsafety.com\/products\/3m-secure-click-d80923-p100-ov-ag-combination-cartridge\"}\n      ],\n      \"isAccessoryOrSparePartFor\": [\n        {\"@type\": \"Product\", \"name\": \"3M HF-801 Small Secure Click Half-Face Respirator\"},\n        {\"@type\": \"Product\", \"name\": \"3M HF-802 Medium Secure Click Half-Face Respirator\"},\n        {\"@type\": \"Product\", \"name\": \"3M HF-803 Large Secure Click Half-Face Respirator\"},\n        {\"@type\": \"Product\", \"name\": \"3M FF-800 Secure Click Full-Face Respirator\"}\n      ]\n    },\n    {\n      \"@type\": \"BreadcrumbList\",\n      \"itemListElement\": [\n        {\"@type\": \"ListItem\", \"position\": 1, \"name\": \"Home\", \"item\": \"https:\/\/wcsafety.com\"},\n        {\"@type\": \"ListItem\", \"position\": 2, \"name\": \"3M Respirator Filters and Cartridges\", \"item\": \"https:\/\/wcsafety.com\/collections\/3m-respirator-filters-and-cartridges\"},\n        {\"@type\": \"ListItem\", \"position\": 3, \"name\": \"3M Secure Click D80921 OV P100 Combination Cartridge, 1 Pair\", \"item\": \"https:\/\/wcsafety.com\/products\/3m-secure-click-d80921-organic-vapor-p100-combination-cartridge-1-pair\"}\n      ]\n    },\n    {\n      \"@type\": \"FAQPage\",\n      \"mainEntity\": [\n        {\"@type\":\"Question\",\"name\":\"What does the '1 pair' designation mean for the D80921 — does the pack include both cartridges?\",\"acceptedAnswer\":{\"@type\":\"Answer\",\"text\":\"Yes. The '1 pair' designation means the package contains two cartridges — one for each port of your HF-800 or FF-800 respirator. Both must be installed simultaneously and replaced together at the same change-out interval.\"}},\n        {\"@type\":\"Question\",\"name\":\"Which size HF-800 half-face respirator should I buy with the D80921?\",\"acceptedAnswer\":{\"@type\":\"Answer\",\"text\":\"The D80921 fits all three HF-800 sizes (HF-801 S, HF-802 M, HF-803 L) with one SKU. Facepiece size is determined by fit test results per your written respiratory protection program. The facepiece and cartridges are ordered separately.\"}},\n        {\"@type\":\"Question\",\"name\":\"Can I use the D80921 with the FF-800 full-face respirator for spray booth work?\",\"acceptedAnswer\":{\"@type\":\"Answer\",\"text\":\"Yes. The D80921 mounts on the FF-800 full-face, increasing APF from 10 to 50 and providing complete eye and face protection from overspray. Cartridge SKU, installation, and change-out schedule are identical on HF-800 and FF-800.\"}},\n        {\"@type\":\"Question\",\"name\":\"Can the D80921 be used for dry sanding and grinding without solvent exposure?\",\"acceptedAnswer\":{\"@type\":\"Answer\",\"text\":\"The P100 filter will protect against particulate, but for pure particulate tasks with no OV hazard, the D3091 P100 filter is the lower-cost option. Use D80921 when both vapor and particulate are confirmed co-hazards; use D3091 for particulate-only tasks.\"}},\n        {\"@type\":\"Question\",\"name\":\"When should I upgrade from the D80921 to the D80923?\",\"acceptedAnswer\":{\"@type\":\"Answer\",\"text\":\"Upgrade to the D80923 when acid gases (Cl2, HCl, SO2, HF) appear on your SDS alongside the OV + particulate hazard. The D80923 adds acid gas sorbent to the same OV + P100 coverage. The D80921 has no acid gas protection.\"}},\n        {\"@type\":\"Question\",\"name\":\"Is the D80921 approved for silica dust from grinding or concrete work with solvent use?\",\"acceptedAnswer\":{\"@type\":\"Answer\",\"text\":\"Yes. The D80921's P100 filter meets OSHA silica standard requirements for silica-generating operations. For silica exposure with no solvent co-hazard, use the standalone D3091 P100 filter at lower cost per pair.\"}},\n        {\"@type\":\"Question\",\"name\":\"How many D80921 pairs do I need per week for a spray painting crew?\",\"acceptedAnswer\":{\"@type\":\"Answer\",\"text\":\"For end-of-shift replacement: workers × shifts per week × 1 pair per shift. Add 15–20% buffer. Document your calculated change-out interval in your written respiratory protection program if multi-shift use is supportable.\"}},\n        {\"@type\":\"Question\",\"name\":\"Is the D80921 appropriate for automotive refinishing shops that also spray 2K urethane clearcoat?\",\"acceptedAnswer\":{\"@type\":\"Answer\",\"text\":\"Only for non-isocyanate portions of the job. The D80921 is not adequate for 2K urethane clearcoats or any product with MDI, HDI, TDI, or diisocyanate hardeners. Isocyanate-containing coatings require a supplied-air respirator per OSHA 29 CFR 1910.94(c).\"}},\n        {\"@type\":\"Question\",\"name\":\"Can I order D80921 cartridges in bulk quantities for a large industrial program?\",\"acceptedAnswer\":{\"@type\":\"Answer\",\"text\":\"Yes. WC Safety stocks the D80921 for individual pair and bulk program ordering. Browse the 3M respirator filters and cartridges collection for current inventory. Contact WC Safety for bulk pricing and recurring replenishment program support.\"}},\n        {\"@type\":\"Question\",\"name\":\"What change-out schedule applies to the D80921 for spray painting operations?\",\"acceptedAnswer\":{\"@type\":\"Answer\",\"text\":\"Use 3M's Chemical Cartridge Service Life Estimation Software for your specific solvent, concentration, humidity, and work rate. End-of-shift replacement is the conservative default for most spray painting operations at or near OSHA PELs. The schedule is driven by the OV sorbent, not the P100 filter. Never extend use based on absence of odor.\"}},\n        {\"@type\":\"Question\",\"name\":\"Is the D80921 the right cartridge for woodworking shops that do both finish spraying and dust sanding?\",\"acceptedAnswer\":{\"@type\":\"Answer\",\"text\":\"Yes. The D80921's OV sorbent covers solvent vapor from lacquers and varnishes; the P100 filter covers wood dust and spray mist. If formaldehyde from composite wood sanding is also present, upgrade to the D80926 multi-gas + P100 which adds formaldehyde sorbent.\"}},\n        {\"@type\":\"Question\",\"name\":\"Where can I read a full evaluation of the D80921 before setting up my spray painting program?\",\"acceptedAnswer\":{\"@type\":\"Answer\",\"text\":\"The 3M Secure Click D80921 review at wcsafety.com covers spray painting applications, the isocyanate exclusion, D80921 vs D80923 comparison, and service life guidance. Browse the 3M respirator filters and cartridges collection for all Secure Click options.\"}}\n      ]\n    },\n    {\n      \"@type\": \"Review\",\n      \"itemReviewed\": {\n        \"@type\": \"Product\",\n        \"name\": \"3M Secure Click D80921 Organic Vapor P100 Combination Cartridge, 1 Pair\",\n        \"url\": \"https:\/\/wcsafety.com\/products\/3m-secure-click-d80921-organic-vapor-p100-combination-cartridge-1-pair\"\n      },\n      \"reviewRating\": {\"@type\": \"Rating\", \"ratingValue\": \"4.7\", \"bestRating\": \"5\", \"worstRating\": \"1\"},\n      \"name\": \"3M Secure Click D80921 Review\",\n      \"reviewBody\": \"Top-rated Secure Click combination cartridge for spray painting, automotive refinishing, and solvent + aerosol environments. Integrated OV + P100 in one positive-lock housing. NIOSH-approved, Secure Click engagement. 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